PIAS 介导的 DNA 双链断裂修复焦点聚焦于 SUMO。

A PIAS-ed view of DNA double strand break repair focuses on SUMO.

机构信息

School of Cancer Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, West Midlands B15 2TT, UK.

出版信息

DNA Repair (Amst). 2010 May 4;9(5):588-92. doi: 10.1016/j.dnarep.2010.02.003. Epub 2010 Mar 1.

DOI:10.1016/j.dnarep.2010.02.003

PMID:20197240

Abstract

Through the action of multiple sensors, mediators, and effectors, the DNA damage response (DDR) orchestrates the repair of DNA damage to ensure maintenance of genomic integrity. Recently, in addition to phosphorylation, other post-translational modifications such as ubiquitylation and SUMOylation have emerged as important regulators of the DDR network. Two recent papers highlight the importance of SUMO modifications of proteins that execute the response to DNA damage.

摘要

通过多种传感器、介质和效应器的作用，DNA 损伤反应 (DDR) 协调修复 DNA 损伤，以确保基因组完整性的维持。最近，除了磷酸化之外，泛素化和 SUMO 化等其他翻译后修饰也成为 DDR 网络的重要调节因子。最近的两篇论文强调了执行 DNA 损伤反应的蛋白质的 SUMO 修饰的重要性。