Suppr超能文献

评价桃金娘科植物(普通桃金娘)浆果在大鼠实验性溃疡模型中的作用。

Evaluation of Myrtus communis Linn. berries (common myrtle) in experimental ulcer models in rats.

机构信息

Department of Ilmul Advia (Pharmacology), Faculty of Unani Medicine, Hamdard University, New Delhi, India.

出版信息

Hum Exp Toxicol. 2010 Nov;29(11):935-44. doi: 10.1177/0960327110364154. Epub 2010 Mar 2.

Abstract

The present study was conducted to investigate the protective effect of the dried berries of Myrtus communis L. in gastric ulcer against ethanol, indomethacin and pyloric ligation induced models in Wistar rats. Two doses of aqueous extracts of M. communis (AE( 1) and AE(2)) at the dose 105 and 175 mg/kg, respectively, and methanolic extracts (ME(1) and ME(2)) at the dose of 93 and 154 mg/kg, respectively, were administered orally to animals prior to the exposure of ulcerogens. The parameters taken to assess anti-ulcer activity were ulcer index, gastric juice volume, gastric pH, total acidity, gastric wall mucus and histopathological studies. Oral administration of AE(1) and AE(2) significantly reduced the ulcer index in all models of ulcers. Low dose of aqueous extract and high dose of methanolic extract of M. communis exhibited more significant effect in comparison to omeprazole (standard drug) in ethanol-induced ulcer model. Both the doses of aqueous and methanolic extracts also reduced the gastric juice volume, total acidity and increased the gastric pH and gastric wall mucus content in all the models of ulcers used in the present study. Histopathological examinations of gastric tissues of rats treated with the aqueous and methanolic extracts in indomethacin-induced ulcer exhibited significant ulcer-protective effect at both the dose levels.

摘要

本研究旨在探讨桃金娘干浆果对乙醇、吲哚美辛和幽门结扎诱导的 Wistar 大鼠胃溃疡的保护作用。分别以 105 和 175mg/kg 的剂量给予桃金娘两种水提物(AE(1)和 AE(2)),以 93 和 154mg/kg 的剂量给予桃金娘两种甲醇提取物(ME(1)和 ME(2)),在暴露于溃疡原之前进行口服给药。用于评估抗溃疡活性的参数包括溃疡指数、胃液量、胃 pH 值、总酸度、胃壁黏液和组织病理学研究。AE(1)和 AE(2)的口服给药显著降低了所有溃疡模型中的溃疡指数。与奥美拉唑(标准药物)相比,低剂量的水提物和高剂量的甲醇提取物在乙醇诱导的溃疡模型中表现出更显著的效果。在本研究中使用的所有溃疡模型中,两种剂量的水提物和甲醇提取物还降低了胃液量、总酸度,增加了胃 pH 值和胃壁黏液含量。在吲哚美辛诱导的溃疡中,用桃金娘水提物和甲醇提取物治疗的大鼠胃组织的组织病理学检查显示出在两个剂量水平上均具有显著的溃疡保护作用。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验