Hallett M, Berardelli A, Matheson J, Rothwell J, Marsden C D
National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892.
J Neurol Neurosurg Psychiatry. 1991 Feb;54(2):124-33. doi: 10.1136/jnnp.54.2.124.
Patients with cerebellar deficits made elbow flexion movements as rapidly as possible for three different angular distances. Electromyographic activity of biceps and triceps and the kinematics of the movements were analysed. Results were compared with those of normal subjects making both rapid and slow movements. In the patients, the first agonist burst of the biceps was frequently prolonged regardless of the distance or speed of the movement. The most striking kinematic abnormality was prolonged acceleration time. The pattern of acceleration time exceeding deceleration time was common in patients but uncommon in normal subjects. The best kinematic correlate of the duration of the first agonist burst was acceleration time. Altered production of appropriate acceleration may therefore be an important abnormality in cerebellar dysfunction for attempted rapid voluntary movements.
患有小脑功能缺陷的患者针对三种不同的角位移尽可能快速地进行肘部屈曲运动。分析了肱二头肌和肱三头肌的肌电活动以及运动的运动学情况。将结果与进行快速和慢速运动的正常受试者的结果进行了比较。在患者中，无论运动的距离或速度如何，肱二头肌的首次主动肌爆发常常延长。最显著的运动学异常是加速时间延长。加速时间超过减速时间的模式在患者中很常见，但在正常受试者中不常见。首次主动肌爆发持续时间的最佳运动学关联因素是加速时间。因此，在试图进行快速自主运动时，适当加速的产生改变可能是小脑功能障碍的一个重要异常情况。
