小脑功能缺损患者简单快速运动的生理学分析。
Physiological analysis of simple rapid movements in patients with cerebellar deficits.
作者信息
Hallett M, Berardelli A, Matheson J, Rothwell J, Marsden C D
机构信息
National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892.
出版信息
J Neurol Neurosurg Psychiatry. 1991 Feb;54(2):124-33. doi: 10.1136/jnnp.54.2.124.
Abstract
Patients with cerebellar deficits made elbow flexion movements as rapidly as possible for three different angular distances. Electromyographic activity of biceps and triceps and the kinematics of the movements were analysed. Results were compared with those of normal subjects making both rapid and slow movements. In the patients, the first agonist burst of the biceps was frequently prolonged regardless of the distance or speed of the movement. The most striking kinematic abnormality was prolonged acceleration time. The pattern of acceleration time exceeding deceleration time was common in patients but uncommon in normal subjects. The best kinematic correlate of the duration of the first agonist burst was acceleration time. Altered production of appropriate acceleration may therefore be an important abnormality in cerebellar dysfunction for attempted rapid voluntary movements.
摘要
患有小脑功能缺陷的患者针对三种不同的角位移尽可能快速地进行肘部屈曲运动。分析了肱二头肌和肱三头肌的肌电活动以及运动的运动学情况。将结果与进行快速和慢速运动的正常受试者的结果进行了比较。在患者中，无论运动的距离或速度如何，肱二头肌的首次主动肌爆发常常延长。最显著的运动学异常是加速时间延长。加速时间超过减速时间的模式在患者中很常见，但在正常受试者中不常见。首次主动肌爆发持续时间的最佳运动学关联因素是加速时间。因此，在试图进行快速自主运动时，适当加速的产生改变可能是小脑功能障碍的一个重要异常情况。
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本文引用的文献
1
A physiological mechanism of bradykinesia.运动迟缓的一种生理机制。
Brain. 1980 Jun;103(2):301-14. doi: 10.1093/brain/103.2.301.
2
Attempted rapid elbow flexion movements in patients with athetosis.手足徐动症患者尝试进行快速屈肘动作。
J Neurol Neurosurg Psychiatry. 1983 Aug;46(8):745-50. doi: 10.1136/jnnp.46.8.745.
3
Duration of the first agonist EMG burst in ballistic arm movements.弹道式手臂运动中首次激动剂肌电图爆发的持续时间。
Brain Res. 1984 Jun 18;304(1):183-7. doi: 10.1016/0006-8993(84)90879-5.
4
Initial agonist burst duration depends on movement amplitude.初始激动剂爆发持续时间取决于运动幅度。
Exp Brain Res. 1984;55(3):523-7. doi: 10.1007/BF00235283.
5
Cerebellar functions in motor control.
Hum Neurobiol. 1984;2(4):251-60.
6
Motor functions of cerebellum and basal ganglia: the cerebellocortical saccadic (ballistic) clock, the cerebellonuclear hold regulator, and the basal ganglia ramp (voluntary speed smooth movement) generator.小脑和基底神经节的运动功能：小脑皮质扫视（弹道式）时钟、小脑核团保持调节器以及基底神经节斜坡（随意速度平滑运动）发生器。
Kybernetik. 1971 Apr;8(4):157-62. doi: 10.1007/BF00290561.
7
Effects of dentate cooling on rapid alternating arm movements.
J Neurophysiol. 1974 Jul;37(4):792-804. doi: 10.1152/jn.1974.37.4.792.
8
Effects of cooling dentate nucleus on tracking-task performance in monkeys.
J Neurophysiol. 1973 Nov;36(6):974-95. doi: 10.1152/jn.1973.36.6.974.
9
Scaling of the size of the first agonist EMG burst during rapid wrist movements in patients with Parkinson's disease.帕金森病患者快速腕部运动期间首个激动剂肌电图爆发的大小缩放。
J Neurol Neurosurg Psychiatry. 1986 Nov;49(11):1273-9. doi: 10.1136/jnnp.49.11.1273.
10
Movement and electromyographic disorders associated with cerebellar dysmetria.与小脑辨距不良相关的运动和肌电图障碍。
J Neurophysiol. 1986 Jun;55(6):1221-33. doi: 10.1152/jn.1986.55.6.1221.
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