Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 1630 Dong Fang Road, 200127, Shanghai, China.
Neurol Sci. 2010 Aug;31(4):431-5. doi: 10.1007/s10072-010-0238-0. Epub 2010 Mar 3.
Blocking or impairment of the sphenopalatine ganglia (SPG) is an effective therapy of cluster headache and other pain syndromes. Contrarily, unilateral SPG-stimulation reduces infarction size in the rat permanent suture model. Well, what are the effects of the SPG damage on the following brain ischemia? This study was aimed to investigate the effects of resection of the nerves bundle from the SPG of rat on the brain lesions following middle cerebral artery occlusion (MCAO), and evaluated the roles of the nitric oxygen synthase (NOS) immunoreactive perivascular nerves of cerebral arteries in MCAO. We found that 7 days after bilateral resections of the nerves bundle from the SPG, the NOS activity perivascular nerves in the middle cerebral arteries disappeared, and the infarction volume and the TUNEL positive cells increased significantly after 24 h MCAO, which implicated that the NOS contained nerves from the SPG maybe have an important role in the MCAO.
阻断或损伤蝶腭神经节（SPG）是治疗丛集性头痛和其他疼痛综合征的有效方法。相反，单侧 SPG 刺激可减少大鼠永久性缝线模型中的梗死面积。那么，SPG 损伤对以下脑缺血有什么影响呢？本研究旨在探讨大鼠 SPG 神经束切除术对大脑中动脉闭塞（MCAO）后脑损伤的影响，并评估脑动脉中一氧化氮合酶（NOS）免疫反应性血管周神经的作用。我们发现，双侧 SPG 神经束切除后 7 天，大脑中动脉的 NOS 活性血管周神经消失，24 小时 MCAO 后梗死体积和 TUNEL 阳性细胞明显增加，这表明 SPG 来源的 NOS 神经可能在 MCAO 中起重要作用。
