C，N-环亚胺基烯丙醛的催化对映选择性 1，3-偶极环加成反应。
Catalytic enantioselective 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines with alpha,beta-unsaturated aldehydes.
机构信息
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
出版信息
J Am Chem Soc. 2010 Mar 31;132(12):4076-7. doi: 10.1021/ja100787a.
PMID:20199072
Abstract
A yet-unexploited class of azomethine imines, C,N-cyclic azomethine imines, could be successfully employed in highly enantioselective 1,3-dipolar cycloaddition with enals catalyzed by titanium-BINOLate to give pharmaceutically attractive tetrahydroisoquinoline and piperidine motifs.
摘要
一类尚未开发的亚胺类化合物，C，N-环亚胺类化合物，可以成功地与钛-BINOLate 催化的烯醛进行高对映选择性 1,3-偶极环加成反应，生成具有吸引力的药物四氢异喹啉和哌啶结构。
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