Lynn Cheng C, Galbraith Sheila, Holland Kristen
Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Pediatr Dermatol. 2010 Jan-Feb;27(1):109-11. doi: 10.1111/j.1525-1470.2009.01057.x.
Neonatal lupus erythematosus is an uncommon disease caused by transplacental passage of maternal anti-Ro (SS-A), anti-LA (SS-B), or anti-U1RNP antibodies. Cutaneous findings of neonatal lupus are variable, but annular, erythematous plaques occurring within a few weeks of birth are most typical. Cutaneous lesions of congenital onset lupus erythematosus can differ from that of neonatal lupus erythematosus, presenting with atrophy or scarring, and less commonly, erosions. We report an unusual case of congenital lupus erythematosus presenting at birth with widespread erosions, pancytopenia, and subsequent hepatobiliary disease.
新生儿红斑狼疮是一种由母体抗Ro（SS-A）、抗La（SS-B）或抗U1RNP抗体经胎盘传递引起的罕见疾病。新生儿狼疮的皮肤表现多种多样，但出生后几周内出现的环形红斑斑块最为典型。先天性红斑狼疮的皮肤病变可能与新生儿红斑狼疮不同，表现为萎缩或瘢痕形成，较少见的是糜烂。我们报告了一例先天性红斑狼疮的罕见病例，患儿出生时即出现广泛糜烂、全血细胞减少，随后出现肝胆疾病。
