Hon Kam Lun, Leung Alexander K C
Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Sciences Building, Shatin, Hong Kong.
Autoimmune Dis. 2012;2012:301274. doi: 10.1155/2012/301274. Epub 2012 Sep 2.
Neonatal lupus erythematosus (NLE) refers to a clinical spectrum of cutaneous, cardiac, and systemic abnormalities observed in newborn infants whose mothers have autoantibodies against Ro/SSA and La/SSB. The condition is rare and usually benign and self-limited but sometimes may be associated with serious sequelae. We review the pathophysiology, clinical features, and management of infants with this condition. Neonates with NLE should be managed at a tertiary care center. Multidisciplinary team involvement may also be indicated. In mothers with anti-Ro/SSA and/or anti-La/SSB antibodies and infants with congenital heart block, the risk of recurrence in subsequent offspring is 17-25%. Therefore, careful monitoring of subsequent pregnancies with serial ultrasonography and echocardiography is essential.
新生儿红斑狼疮（NLE）是指在母亲具有抗Ro/SSA和La/SSB自身抗体的新生儿中观察到的一系列皮肤、心脏和全身异常的临床症状。这种情况很罕见，通常为良性且具有自限性，但有时可能会伴有严重的后遗症。我们回顾了患有这种疾病的婴儿的病理生理学、临床特征和治疗方法。患有NLE的新生儿应在三级医疗中心接受治疗。也可能需要多学科团队的参与。对于有抗Ro/SSA和/或抗La/SSB抗体的母亲以及患有先天性心脏传导阻滞的婴儿，后续子代复发的风险为17%-25%。因此，通过连续超声检查和超声心动图对后续妊娠进行仔细监测至关重要。
