Crowley E, Frieden I J
University of Illinois, College of Medicine, Urbana, USA.
Pediatr Dermatol. 1998 Jan-Feb;15(1):38-42. doi: 10.1046/j.1525-1470.1998.1998015038.x.
Neonatal lupus erythematosus (NLE) is a rare disorder believed to be caused by the transplacental passage of specific autoantibodies from the mother to the fetus. Affected infants typically present with either characteristic skin lesions developing in the first month or later in life or congenital heart block. We report a very unusual case of NLE that was characterized by congenital skin atrophy, erosions, alopecia, and profound pancytopenia. Ro, La, and RNP antibodies were absent, and the diagnosis was made because of light microscopic and immunofluorescent findings. This case emphasizes that NLE can have widespread congenital skin involvement and suggests that at least some cases are mediated by antibodies other than Ro, La, and RNP.
新生儿红斑狼疮（NLE）是一种罕见的疾病，被认为是由特定自身抗体经胎盘从母亲传递给胎儿所致。受影响的婴儿通常在出生后第一个月或更晚出现特征性皮肤病变或先天性心脏传导阻滞。我们报告了一例非常罕见的NLE病例，其特征为先天性皮肤萎缩、糜烂、脱发和严重全血细胞减少。未检测到Ro、La和RNP抗体，诊断基于光镜和免疫荧光检查结果。该病例强调NLE可出现广泛的先天性皮肤受累，并提示至少部分病例是由Ro、La和RNP以外的抗体介导的。
