Haramura Tomoko, Haraguchi Masashi, Irie Junji, Ito Shinichiro, Tokai Hirotaka, Noda Kazumasa, Kitajima Masachika, Minami Shigeki, Inoue Keiji, Sasaki Yuya, Oshima Koichi, Eguchi Susumu
Tomoko Haramura, Masashi Haraguchi, Shinichiro Ito, Hirotaka Tokai, Kazumasa Noda, Masachika Kitajima, Shigeki Minami, Keiji Inoue, Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki 850-8555, Japan.
World J Gastroenterol. 2015 Jun 28;21(24):7598-603. doi: 10.3748/wjg.v21.i24.7598.
Plasmablastic lymphoma (PBL) is a rare form of non-Hodgkin's lymphoma that is associated with human immunodeficiency virus (HIV) infection. Although PBL is most commonly observed in the oral cavity of HIV-positive patients, it can also be observed at extra-oral sites in HIV-negative patients. This report represents an unusual case of HIV-negative PBL that occurred in the sigmoid colon. This patient had a history of systemic lupus erythematosus and an underlying immunosuppressive state from long term steroid therapy. The lymphoma cells were positive for CD138, kappa light chain restriction and Epstein-Barr virus and negative for CD20/L26, CD3, CD79a, UCHL1 (CD45RO) and cytokeratin (AE1/AE3). The patient died approximately 2 mo after the operation. In the present paper, we review cases of PBL of the colon in HIV-negative patients.
浆母细胞淋巴瘤（PBL）是一种罕见的非霍奇金淋巴瘤，与人类免疫缺陷病毒（HIV）感染有关。虽然PBL最常见于HIV阳性患者的口腔，但也可在HIV阴性患者的口腔外部位观察到。本报告介绍了一例发生在乙状结肠的HIV阴性PBL罕见病例。该患者有系统性红斑狼疮病史，长期接受类固醇治疗导致潜在的免疫抑制状态。淋巴瘤细胞CD138、κ轻链限制和EB病毒呈阳性，而CD20/L26、CD3、CD79a、UCHL1（CD45RO）和细胞角蛋白（AE1/AE3）呈阴性。患者术后约2个月死亡。在本文中，我们回顾了HIV阴性患者结肠PBL的病例。
