Department of Pediatrics, Section of Nutrition, University of Colorado Denver, Aurora, CO 80045, USA.
Am J Clin Nutr. 2010 May;91(5):1430S-1432S. doi: 10.3945/ajcn.2010.28674B. Epub 2010 Mar 3.
This article provides a review of how the challenge of bioavailability was approached in establishing the Dietary Reference Intakes, with a special focus on folic acid, vitamin B-12, beta-carotene, iron, selenium, and zinc, the targeted micronutrients for this workshop. In a future perspective, the necessity of having a clear working definition of bioavailability is emphasized. The bioavailability of micronutrients should be considered, with advantage, under subheadings determined by the broad factors that affect bioavailability. Special emphasis is given to giving greater and specific attention to factors involved in the maintenance of homeostasis. These factors, it is argued, are best considered separately from even a broad definition of bioavailability and have the potential to provide new insights into some micronutrient requirements.
本文回顾了在制定膳食参考摄入量时如何应对生物利用度挑战，特别关注叶酸、维生素 B-12、β-胡萝卜素、铁、硒和锌这 6 种 Workshop 目标微量营养素。从未来展望来看，强调了明确生物利用度工作定义的必要性。应该根据影响生物利用度的广泛因素，以副标题形式考虑微量营养素的生物利用度。特别强调要更加关注和具体关注维持体内平衡所涉及的因素。有人认为，即使从广义的生物利用度定义来看，这些因素也最好单独考虑，并且有可能为一些微量营养素需求提供新的见解。
