聚集放线杆菌白细胞毒素：从威胁到治疗。
Aggregatibacter actinomycetemcomitans leukotoxin: from threat to therapy.
机构信息
Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, 185 S. Orange Avenue, Medical Science Building C-636, Newark, NJ 07103, USA.
出版信息
J Dent Res. 2010 Jun;89(6):561-70. doi: 10.1177/0022034510363682. Epub 2010 Mar 3.
Abstract
Aggregatibacter actinomycetemcomitans is a Gram-negative bacterium that colonizes the human oral cavity and is the causative agent for localized aggressive periodontitis (LAP), an aggressive form of periodontal disease that occurs in adolescents. A. actinomycetemcomitans secretes a protein toxin, leukotoxin (LtxA), which helps the bacterium evade the host immune response during infection. LtxA is a membrane-active toxin that specifically targets white blood cells (WBCs). In this review, we discuss recent developments in this field, including the identification and characterization of genes and proteins involved in secretion, regulation of LtxA, biosynthesis, newly described activities of LtxA, and how LtxA may be used as a therapy for the treatment of diseases.
摘要
伴放线放线杆菌是一种革兰氏阴性菌，定植于人类口腔，是导致局限性侵袭性牙周炎（LAP）的病原体，LAP 是一种发生在青少年中的侵袭性牙周病。伴放线放线杆菌分泌一种蛋白毒素，白细胞毒素（LtxA），帮助细菌在感染过程中逃避宿主免疫反应。LtxA 是一种膜活性毒素，专门针对白细胞（WBC）。在这篇综述中，我们讨论了这一领域的最新进展，包括参与分泌的基因和蛋白的鉴定和特征、LtxA 的调控、生物合成、LtxA 的新描述的活性，以及 LtxA 如何被用作治疗疾病的一种疗法。
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