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白细胞毒素 (LtxA；Leukothera)：作用机制与治疗应用。

Leukotoxin (LtxA; Leukothera): Mechanisms of Action and Therapeutic Applications.

机构信息

Department of Oral Biology, Rutgers School of Dental Medicine, Newark, NJ 07103, USA.

Actinobac Biomed, Inc., Princeton, NJ 08540, USA.

出版信息

Toxins (Basel). 2019 Aug 26;11(9):489. doi: 10.3390/toxins11090489.

DOI:10.3390/toxins11090489
PMID:31454891
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6784247/
Abstract

is an oral pathogen that produces the RTX toxin, leukotoxin (LtxA; Leukothera). is strongly associated with the development of localized aggressive periodontitis. LtxA acts as a virulence factor for to subvert the host immune response by binding to the β integrin lymphocyte function-associated antigen-1 (LFA-1; CD11a/CD18) on white blood cells (WBCs), causing cell death. In this paper, we reviewed the state of knowledge on LtxA interaction with WBCs and the subsequent mechanisms of induced cell death. Finally, we touched on the potential therapeutic applications of LtxA (trade name Leukothera) toxin therapy for the treatment of hematological malignancies and immune-mediated diseases.

摘要

是一种口腔病原体，能产生 RTX 毒素和白细胞毒素（LtxA；Leukothera）。 与局限性侵袭性牙周炎的发展密切相关。LtxA 作为一种毒力因子，通过与白细胞（WBC）上的 β 整合素淋巴细胞功能相关抗原-1（LFA-1；CD11a/CD18）结合，破坏宿主的免疫反应，导致细胞死亡。本文综述了 LtxA 与 WBC 相互作用及其诱导细胞死亡的后续机制的研究现状。最后，我们还探讨了 LtxA（商品名 Leukothera）毒素治疗在治疗血液系统恶性肿瘤和免疫介导性疾病方面的潜在治疗应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc7a/6784247/3e6657c1a463/toxins-11-00489-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc7a/6784247/74de8f6bf1ec/toxins-11-00489-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc7a/6784247/45e3a41d94ec/toxins-11-00489-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc7a/6784247/3e6657c1a463/toxins-11-00489-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc7a/6784247/74de8f6bf1ec/toxins-11-00489-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc7a/6784247/45e3a41d94ec/toxins-11-00489-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc7a/6784247/3e6657c1a463/toxins-11-00489-g003.jpg

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2
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