Key Laboratory of Analytical Sciences, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Anal Chem. 2010 Apr 1;82(7):3077-80. doi: 10.1021/ac902981j.
The capabilities of two-dimensional separation using a high irradiance laser ionization orthogonal time-of-flight mass spectrometer (LI-O-TOFMS) were demonstrated in this paper. Ions were separated via their initial kinetic energy in one dimension and their mass-to-charge ratios in the other dimension. Investigation of the transient ion profiles after laser pulses revealed that the separation of analyte ions from multiply charged ions and gas species ions was achieved. Comparison of mass spectra in the normal accumulation mode and in the two-dimensional separation mode indicated that the relative sensitivity coefficients are stable and close to their true values in the two-dimensional separation mode, especially for trace elements that are prone to interference.
本文展示了使用高辐照度激光电离正交飞行时间质谱仪（LI-O-TOFMS）进行二维分离的能力。离子通过初始动能在一维方向上分离，通过质荷比在另一维方向上分离。激光脉冲后瞬态离子轮廓的研究表明，实现了分析物离子与多电荷离子和气体种类离子的分离。在常规累积模式和二维分离模式下的质谱比较表明，相对灵敏度系数在二维分离模式下是稳定的，且接近真实值，特别是对于容易受到干扰的微量元素。
