Lancaster University, Lancaster, UK.
Epidemiol Infect. 2010 Oct;138(10):1384-90. doi: 10.1017/S0950268810000488. Epub 2010 Mar 5.
A total of 969 isolates of Campylobacter jejuni originating in the Preston, Lancashire postcode district over a 3-year period were characterized using multi-locus sequence typing. Recently developed statistical methods and a genetic model were used to investigate temporal, spatial, spatio-temporal and genetic variation in human C. jejuni infections. The analysis of the data showed statistically significant seasonal variation, spatial clustering, small-scale spatio-temporal clustering and spatio-temporal interaction in the overall pattern of incidence, and spatial segregation in cases classified according to their most likely species-of-origin.
在三年内，总共对来自兰开夏郡普雷斯顿邮政编码区的 969 株空肠弯曲菌分离株进行了多位点序列分型特征分析。最近开发的统计方法和遗传模型被用于研究人类空肠弯曲菌感染的时间、空间、时空和遗传变异。数据分析显示，在总体发病率模式中存在统计学上显著的季节性变化、空间聚类、小尺度时空聚类和时空相互作用，以及根据最可能的起源物种对病例进行分类时的空间分离。
