Department of Public Health, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Emerg Infect Dis. 2010 Mar;16(3):493-6. doi: 10.3201/eid1603.091321.
In 2007 and 2008 in Myanmar, we detected influenza viruses A (H3N2) that exhibited reduced sensitivity to both zanamivir and amantadine. These rare and naturally occurring viruses harbored a novel Q136K mutation in neuraminidase and S31N mutation in M2.
在 2007 年和 2008 年的缅甸,我们检测到了对扎那米韦和金刚烷胺均表现出降低敏感性的甲型流感病毒(H3N2)。这些罕见且自然发生的病毒在神经氨酸酶中具有新型的 Q136K 突变,在 M2 中具有 S31N 突变。