Department of Clinical Chemistry, New Cross Hospital, Wolverhampton, West Midlands WV10 0QP, UK.
J Clin Pathol. 2010 Mar;63(3):278-80. doi: 10.1136/jcp.2009.065821.
To determine whether ethnic differences exist in glycated haemoglobin between white subjects and those of South Asian origin with normal glucose tolerance (NGT) METHODS: Erythrocyte glycated haemoglobin (HbA(1c)) was compared between white subjects and those of South Asian origin with NGT defined by a 75 g oral glucose tolerance test (OGTT).
139 subjects with NGT comprising 36 people of South Asian origin (20 female) and 103 white subjects (49 female) were compared. Subjects of South Asian origin were younger (p<0.001) and weighed less (p<0.001) than white subjects. Fasting and 2 h capillary plasma glucose concentrations were similar in subjects of South Asian origin and white subjects, but HbA(1c) levels were higher (p<0.05) in subjects of South Asian origin (6.11+/-0.58%) compared with levels in white subjects (5.90+/-0.40%).
In subjects with similar fasting and postprandial glycaemia on OGTT, those of South Asian origin have higher HbA(1c) levels than white subjects. It is speculated that the higher glycaemia-independent HBA(1c) levels in people of South Asian origin could possibly contribute to their increase cardiovascular risk.
确定在血糖正常的白种人和南亚裔人群中，糖化血红蛋白是否存在种族差异。
通过 75g 口服葡萄糖耐量试验（OGTT）来定义血糖正常（NGT），比较白种人和南亚裔人群的红细胞糖化血红蛋白（HbA(1c)）。
共比较了 139 例 NGT 患者，包括 36 名南亚裔（20 名女性）和 103 名白种人（49 名女性）。南亚裔人群的年龄（p<0.001）和体重（p<0.001）均小于白种人。南亚裔人群和白种人空腹和 2 小时毛细血管血糖浓度相似，但南亚裔人群的 HbA(1c)水平（6.11+/-0.58%）高于白种人（5.90+/-0.40%）（p<0.05）。
在 OGTT 时具有相似空腹和餐后血糖的情况下，南亚裔人群的 HbA(1c)水平高于白种人。推测南亚裔人群的血糖非依赖性 HbA(1c)水平升高可能导致其心血管风险增加。
