慢性透析患者血清、血浆、血小板及尿液中的免疫反应性表皮生长因子

Immunoreactive epidermal growth factor in serum, plasma, platelets, and urine in patients on chronic dialysis.

作者信息

Lev-Ran A, Hwang D L, Ahmad B, Bixby H

机构信息

City of Hope National Medical Center, Duarte, Calif.

出版信息

Nephron. 1991;57(2):164-6. doi: 10.1159/000186244.

DOI:10.1159/000186244

PMID:2020343

Abstract

In 25 patients with chronic renal failure undergoing hemodialysis the level of epidermal growth factor (EGF) was significantly increased in plasma (61 +/- 10 vs. 36 +/- 12 pM in 23 aged-matched controls; p less than 0.0001) and serum (189 +/- 51 vs. 138 +/- 69 pM, p less than 0.006) and slightly increased in platelets (391 +/- 134 vs. 308 +/- 87 aM/10(6) platelets in controls; p less than 0.0582). In those 15 patients who produced urine, EGF was absent or close to the low limit of the sensitivity of the method (17 pM). Thus, kidneys are not delivering EGF to blood but their role in EGF removal is possible. Urinary EGF virtually disappears in severe chronic renal failure.

摘要

在25例接受血液透析的慢性肾衰竭患者中，血浆中表皮生长因子（EGF）水平显著升高（61±10 pM，而23例年龄匹配的对照组为36±12 pM；p<0.0001），血清中也显著升高（189±51 pM，对照组为138±69 pM，p<0.006），血小板中略有升高（391±134 aM/10⁶血小板，对照组为308±87 aM/10⁶血小板；p<0.0582）。在仍有尿液生成的15例患者中，EGF缺失或接近该检测方法的灵敏度下限（17 pM）。因此，肾脏并非向血液中输送EGF，但它们在清除EGF方面可能发挥作用。在严重慢性肾衰竭时，尿EGF实际上消失。