Braguer D, Gallice P, Yatzidis H, Berland Y, Crevat A
Laboratoire de Biophysique, Faculté de Pharmacie, Marseille, France.
Nephron. 1991;57(2):192-6. doi: 10.1159/000186249.
Tubulin is an intracellular protein whose in vivo polymerization leads to the formation of microtubules (MT). MT are essential component of axons of nerve cells. This reaction is the limiting factor in the growth of axons. Uremic neuropathy is characterized in part by an axonal degeneration. A chromatographic fraction from uremic plasma (2-5 fraction) inhibits in vitro the tubulin polymerization and thus MT formation and therefore may be implicated in the occurrence of uremic neuropathy. In vitro, biotin counteracts the inhibitory effect of 2-5 fraction on MT formation. This effect could be a partial explanation of the possible clinical improvement brought on by biotin in uremic neuropathy.
微管蛋白是一种细胞内蛋白质，其在体内聚合会导致微管（MT）的形成。微管是神经细胞轴突的重要组成部分。该反应是轴突生长的限制因素。尿毒症神经病变部分特征为轴突退变。尿毒症血浆的一个色谱级分（2 - 5级分）在体外抑制微管蛋白聚合，进而抑制微管形成，因此可能与尿毒症神经病变的发生有关。在体外，生物素可抵消2 - 5级分对微管形成的抑制作用。这种作用可能部分解释了生物素对尿毒症神经病变可能带来的临床改善。
