Center for Neuroscience and Cell Biology of Coimbra, Department of Life Sciences, School of Science and Technology, University of Coimbra, 3004-517 Coimbra, Portugal.
Mini Rev Med Chem. 2009 Nov 1;9(13):1556-67. doi: 10.2174/138955709790361548.
Non-ionic surfactants have been proposed as dual action anti-viral and spermicidal agents to tackle viral infections, namely HIV. Given very promising in vitro results, nonoxynol-9 has been widely used. However, toxic effects were reported, paradoxically increasing the incidence of transmission of HIV/Sexually Transmitted Diseases in vivo. Thus, there has been a growing interest in identifying and evaluating a new generation of accessible and easy-to-use molecules with simultaneous spermicidal and microbicide action. Different biochemical compounds and mechanisms of action are currently being studied. This article reviews the diverse strategies and mechanisms of action of these novel compounds, as well the necessary systematic studies needed to evaluate their possible toxicity.
非离子型表面活性剂被提议作为双重作用的抗病毒和杀精子剂，以应对病毒感染，即 HIV。鉴于非常有前途的体外结果，壬苯醇醚-9 已被广泛使用。然而，据报道有毒性作用，反而增加了 HIV/性传播疾病在体内的传播发生率。因此，人们越来越有兴趣识别和评估新一代可用且易于使用的同时具有杀精子和杀微生物作用的分子。目前正在研究不同的生化化合物和作用机制。本文综述了这些新型化合物的多种策略和作用机制，以及评估其潜在毒性所需的必要系统研究。
