Department of Molecular Imaging, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-Ku, Sapporo, Hokkaido 060-8638, Japan. kyoshi2med.hokudai.ac.jp
J Cardiol. 2010 Mar;55(2):163-73. doi: 10.1016/j.jjcc.2010.01.001. Epub 2010 Feb 8.
Cardiovascular disease is the leading cause of death in modern industrialized countries with an aging population. This fact has fueled the need for innovative diagnostic testing intended to improve coronary artery disease (CAD) patient care. Detection of myocardial ischemia using myocardial perfusion imaging (MPI) plays an important role for CAD diagnosis and the prediction of future risk of cardiovascular events. Positron emission tomography (PET) MPI has high diagnostic accuracy and can estimate regional myocardial blood flow (MBF) in patients with CAD. Rubidium-82 ((82)Rb) is a generator-produced PET myocardial perfusion tracer and has been widely used in North America in clinical practice. (82)Rb PET has recently become available in some cardiovascular centers in Europe and Japan. Clinical trials are expected in both regions. (82)Rb PET has high diagnostic accuracy and recent data have shown its prognostic value. Thus, (82)Rb PET would greatly contribute to CAD patients' care. (82)Rb PET can also be used to quantify MBF. This review describes the current status of (82)Rb MPI from basic principles to clinical implications. This paper also highlights the recent development of MBF quantification using (82)Rb PET.
心血管疾病是人口老龄化的现代工业化国家的主要死亡原因。这一事实推动了创新诊断检测的需求，旨在改善冠心病（CAD）患者的护理。使用心肌灌注成像（MPI）检测心肌缺血在 CAD 诊断和预测未来心血管事件风险方面发挥着重要作用。正电子发射断层扫描（PET）MPI 具有较高的诊断准确性，可用于估计 CAD 患者的局部心肌血流（MBF）。放射性核素 82 铷（82 Rb）是一种发生器生产的 PET 心肌灌注示踪剂，已在北美临床实践中广泛使用。（82）Rb PET 最近在欧洲和日本的一些心血管中心也有应用。预计这两个地区都将进行临床试验。（82）Rb PET 具有较高的诊断准确性，最近的数据显示了其预后价值。因此，（82）Rb PET 将极大地有助于 CAD 患者的护理。（82）Rb PET 还可用于定量 MBF。本综述从基本原理到临床意义描述了（82）Rb MPI 的现状。本文还重点介绍了使用（82）Rb PET 定量 MBF 的最新进展。
