Department of Molecular Imaging, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Circ J. 2013;77(7):1662-71. doi: 10.1253/circj.cj-13-0235. Epub 2013 May 23.
Myocardial perfusion imaging (MPI) has played an important role in the diagnosis and risk assessment of coronary artery disease (CAD) since the early 1970s. Positron emission tomography (PET) MPI has high diagnostic accuracy and prognostic value. PET MPI can also be used to quantitatively evaluate regional myocardial blood flow (MBF) through a mathematical model. PET MBF measurements can be used in evaluating early-stage atherosclerosis with endothelial dysfunction right through to diagnosing CAD. PET/computed tomography scanners are now found in many facilities across North America, Europe, and Asia, and PET MBF quantification is expected to move from strictly research to more clinical applications. Nuclear cardiology has been a leader in quantification approaches that can be applied to other new imaging modalities. Therefore, it would be valuable to understand the basic aspects of quantification approaches. This review will address the basic aspects of MBF quantification and the additional value of quantification approaches in the clinical setting.
自 20 世纪 70 年代初以来，心肌灌注成像（MPI）在冠心病（CAD）的诊断和风险评估中发挥了重要作用。正电子发射断层扫描（PET）MPI 具有较高的诊断准确性和预后价值。PET MPI 还可以通过数学模型定量评估局部心肌血流（MBF）。PET MBF 测量可用于评估从内皮功能障碍的早期动脉粥样硬化到诊断 CAD。目前，北美、欧洲和亚洲的许多机构都配备了 PET/CT 扫描仪，预计 PET MBF 定量将从严格的研究转向更多的临床应用。核心脏病学一直处于可应用于其他新型成像模式的定量方法的领先地位。因此，了解定量方法的基本方面将具有重要价值。本文将介绍 MBF 定量的基本方面以及定量方法在临床环境中的附加价值。
