Department of Radiological Sciences, Unit of Nuclear Medicine, University of Messina, Messina, Italy.
Ann Endocrinol (Paris). 2010 Mar;71(2):127-30. doi: 10.1016/j.ando.2010.01.004. Epub 2010 Mar 6.
Single or multiple thyroid metastases from extra-thyroid primary tumors are reported to be rare. Malignancies that metastasize to the thyroid include cancers originating from lung, breast and kidney. We report our experience with a case of thyroid metastases, which were detected 18 years after curative kidney surgery for renal cell carcinoma. After 18 years, the patients noted the sudden appearance of a lump in the neck. Ultrasonography showed the presence of a multinodular goiter, all nodules being "cold" at scintiscan. Total thyroidectomy was performed; histology of all nodules revealed a metastatic thyroid cancer from renal cell carcinoma. The patient was still alive and in good health 16 months after thyroidectomy. History of patients with thyroid nodules should include inquiring about extra-thyroid malignancies, especially renal cell carcinoma, that may have been diagnosed even many years earlier. As a corollary, follow-up of such patients should include periodic thyroid exploration or at least a physical examination.
甲状腺转移灶来自甲状腺外原发肿瘤的情况较为少见。可转移至甲状腺的恶性肿瘤包括来源于肺、乳腺和肾脏的癌症。我们报告了 1 例肾细胞癌根治术后 18 年发现甲状腺转移的病例。18 年后，患者出现颈部肿块。超声检查显示为多发性结节性甲状腺肿，所有结节在闪烁扫描时均呈“冷”区。行甲状腺全切除术；所有结节的组织学均显示为肾细胞癌的转移性甲状腺癌。甲状腺切除术后 16 个月，患者仍存活且身体状况良好。有甲状腺结节病史的患者应询问是否有甲状腺外恶性肿瘤，特别是肾细胞癌，即使在很多年前被诊断出来，也应询问。相应地，此类患者的随访应包括定期进行甲状腺探查或至少进行体格检查。
