MTNR1B 常见遗传变异与多囊卵巢综合征患者的血清睾酮、葡萄糖耐量和胰岛素分泌有关。
Common genetic variation in MTNR1B is associated with serum testosterone, glucose tolerance, and insulin secretion in polycystic ovary syndrome patients.
机构信息
Institutes of Biomedical Science, Fudan University, Shanghai, People's Republic of China.
出版信息
Fertil Steril. 2010 Nov;94(6):2486-9, 2489.e1-2. doi: 10.1016/j.fertnstert.2010.01.059. Epub 2010 Mar 6.
Abstract
Melatonin plays an important role in many aspects of the human reproductive process. Our results first strongly suggest that MTNR1B mediating some functions of melatonin contributes to the phenotypic expression of polycystic ovary syndrome, which provide a new insight into the role of MTNR1B gene in the pathophysiology of the disease.
摘要
褪黑素在人类生殖过程的许多方面发挥着重要作用。我们的研究结果首先有力地表明，介导褪黑素某些功能的 MTNR1B 有助于多囊卵巢综合征的表型表达，这为 MTNR1B 基因在疾病病理生理学中的作用提供了新的认识。
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