Eskisehir Osmangazi University, Department of Pediatric Gastroenterology and Hepatology, Eskisehir, Turkey.
Am J Trop Med Hyg. 2010 Mar;82(3):488-91. doi: 10.4269/ajtmh.2010.09-0529.
The purpose of this trial is to evaluate the clinical efficacy and cost/effectiveness of Saccharomyces boulardii compared with yogurt fluid (YF) in acute non-bloody diarrhea in children. This randomized, prospective open-label clinical trial includes 55 children (36 boys, 19 girls; mean age 21.2 +/- 28.2 months). Group A (N = 28) received lyophilized S. boulardii and group B (N = 27) received YF. The duration of diarrhea was shorter with S. boulardii but the hospital stay was reduced with YF, although these differences were not significant. However, diarrhea had resolved in significantly more children on day 3 in the S. boulardii group (48.5% versus 25.5%; P < 0.05). In outpatient cases, yogurt treatment was cheaper than S. boulardii whereas in hospitalized patients, treatment cost was similar. In conclusion, the effect of daily freshly prepared YF was comparable to S. boulardii in the treatment of acute non-bloody diarrhea in children. The duration of diarrhea was shorter in the S. boulardii group, expressed as a significantly higher number of patients with normal stools on day 3.
本试验旨在评估布拉氏酵母菌散剂（Saccharomyces boulardii）与酸奶液（Yogurt Fluid，YF）治疗儿童急性非血性腹泻的临床疗效和成本/效果。这是一项随机、前瞻性、开放标签临床试验，纳入了 55 名儿童（男 36 名，女 19 名；平均年龄 21.2±28.2 个月）。A 组（n=28）接受冻干布拉氏酵母菌散剂治疗，B 组（n=27）接受酸奶液治疗。虽然差异无统计学意义，但与 YF 相比，S. boulardii 组的腹泻持续时间更短，而 YF 组的住院时间更短。然而，在第 3 天，S. boulardii 组中腹泻已缓解的患儿比例显著更高（48.5%对 25.5%；P＜0.05）。在门诊病例中，酸奶液治疗的费用低于布拉氏酵母菌散剂，而在住院患者中，两种治疗的费用相似。总之，在治疗儿童急性非血性腹泻方面，每日新鲜制备的 YF 的效果与 S. boulardii 相当。S. boulardii 组的腹泻持续时间更短，第 3 天大便正常的患儿比例显著更高。
