Vandenplas Yvan, Brunser Oscar, Szajewska Hania
Universitair Ziekenhuis Kinderen Brussel, Vrije Universiteit Brussel, Laarbeekl 101, 1090, Brussels, Belgium.
Eur J Pediatr. 2009 Mar;168(3):253-65. doi: 10.1007/s00431-008-0879-7. Epub 2008 Dec 19.
Probiotics are live microorganisms which confer a health benefit on the host. Saccharomyces boulardii, a yeast, has been found to be an effective probiotic in double-blind placebo-controlled randomized clinical studies.
We reviewed the established mechanisms of actions and clinical efficacy in children of S. boulardii.
The mechanisms of action of S. boulardii depend mainly on the inhibition of some bacterial toxins, anti-inflammatory effects, and on stimulating effects on the intestinal mucosa such as trophic effects on the brush border enzymes and immunostimulatory effects. At present, in pediatric populations, there is evidence that S. boulardii is beneficial for the treatment of acute gastroenteritis and the prevention of antibiotic-associated diarrhea. More data are needed in other indications such as traveller's diarrhea, Helicobacter pylori eradication, and inflammatory bowel disease. S. boulardii is a yeast strain that has been extensively studied in vitro and in vivo. Recent data have opened the door for new therapeutic indications.
益生菌是对宿主有益的活微生物。布拉酵母菌，一种酵母，在双盲安慰剂对照随机临床研究中已被发现是一种有效的益生菌。
我们回顾了布拉酵母菌在儿童中的既定作用机制和临床疗效。
布拉酵母菌的作用机制主要取决于对某些细菌毒素的抑制、抗炎作用以及对肠黏膜的刺激作用，如对刷状缘酶的营养作用和免疫刺激作用。目前，在儿科人群中，有证据表明布拉酵母菌对治疗急性胃肠炎和预防抗生素相关性腹泻有益。在其他适应症如旅行者腹泻、幽门螺杆菌根除和炎症性肠病方面，还需要更多数据。布拉酵母菌是一种已在体外和体内得到广泛研究的酵母菌株。最新数据为新的治疗适应症打开了大门。
