Singapore Eye Research Institute, Singapore National Eye Center, Singapore.
Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3736-41. doi: 10.1167/iovs.09-5008. Epub 2010 Mar 5.
PURPOSE. To describe the association of retinal vascular tortuosity, measured quantitatively, with the neuroretinal rim. METHODS. A population-based, cross-sectional study was conducted in Malay persons aged 40 to 80 years residing in Singapore. Retinal vascular tortuosity was quantified by using a semiautomated, computer-assisted program assessing retinal fundus photographs, according to a standardized protocol. Optic disc measurements including disc area, rim area, and rim-to-disc area (RDA) ratio were obtained with a confocal scanning laser ophthalmoscope. RESULTS. In analyses adjusting for age, sex, spherical equivalent, and retinal vascular caliber, reduced arteriolar and venular tortuosity were associated with a decrease in global RDA ratio (P = 0.006 and P = 0.001, respectively). When compared with the arterioles, retinal venular tortuosity demonstrated a stronger association with RDA ratio. The temporal-inferior region of the neuroretinal rim was most strongly associated with retinal vascular tortuosity. CONCLUSIONS. Straighter retinal vessels were significantly associated with a thinning neuroretinal rim. These findings may provide additional insights into the geometric retinal vascular changes seen in early glaucomatous optic neuropathy.
目的。描述定量测量的视网膜血管迂曲与神经视网膜边缘之间的关系。
方法。在新加坡居住的 40 至 80 岁的马来人群体中进行了一项基于人群的横断面研究。根据标准化方案，使用半自动、计算机辅助程序评估眼底照片来量化视网膜血管迂曲程度。使用共焦扫描激光检眼镜获得包括视盘面积、边缘面积和边缘到视盘面积比（RDA）在内的视盘测量值。
结果。在调整年龄、性别、等效球镜和视网膜血管口径后，动脉和静脉迂曲程度的降低与全球 RDA 比值的降低相关（P=0.006 和 P=0.001）。与动脉相比，视网膜静脉迂曲与 RDA 比值的相关性更强。神经视网膜边缘的颞下区域与视网膜血管迂曲的相关性最强。
结论。视网膜血管越直，神经视网膜边缘越薄。这些发现可能为早期青光眼性视神经病变中所见的几何视网膜血管变化提供更多的见解。
