在黄色粘球菌中异源表达土霉素生物合成途径。
Heterologous expression of the oxytetracycline biosynthetic pathway in Myxococcus xanthus.
机构信息
Department of Chemistry, Syracuse University, Syracuse, New York 132441, USA.
出版信息
Appl Environ Microbiol. 2010 Apr;76(8):2681-3. doi: 10.1128/AEM.02841-09. Epub 2010 Mar 5.
Abstract
New natural products for drug discovery may be accessed by heterologous expression of bacterial biosynthetic pathways in metagenomic DNA libraries. However, a "universal" host is needed for this experiment. Herein, we show that Myxococcus xanthus is a potential "universal" host for heterologous expression of polyketide biosynthetic gene clusters.
摘要
通过在宏基因组 DNA 文库中异源表达细菌生物合成途径，可能获得新的药物发现天然产物。然而，这种实验需要一种“通用”宿主。本文中，我们证明了粘球菌属（Myxococcus xanthus）是聚酮生物合成基因簇异源表达的潜在“通用”宿主。
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