小动物皮质血流的实时光声断层成像。
Real-time photoacoustic tomography of cortical hemodynamics in small animals.
出版信息
J Biomed Opt. 2010 Jan-Feb;15(1):010509. doi: 10.1117/1.3302807.
Abstract
For the first time, the hemodynamics within the entire cerebral cortex of a mouse were studied by using photoacoustic tomography (PAT) in real time. The PAT system, based on a 512-element full-ring ultrasound array, received photoacoustic signals primarily from a slice of 2-mm thickness. This system can provide high-resolution brain vasculature images. We also monitored the fast wash-in process of a photoacoustic contrast agent in the mouse brain. Our results demonstrated that PAT is a powerful imaging modality that can be potentially used to study small animal neurofunctional activities.
摘要
首次通过光声断层扫描（PAT）实时研究了小鼠整个大脑皮层内的血液动力学。该 PAT 系统基于 512 个单元的全环超声阵列，主要从 2 毫米厚的切片接收光声信号。该系统可以提供高分辨率的大脑血管图像。我们还监测了光声对比剂在小鼠大脑中的快速灌注过程。我们的结果表明，PAT 是一种强大的成像方式，可用于研究小动物的神经功能活动。
相似文献
1
Real-time photoacoustic tomography of cortical hemodynamics in small animals.
J Biomed Opt. 2010 Jan-Feb;15(1):010509. doi: 10.1117/1.3302807.
2
Photoacoustic imaging of lymphatic pumping.
J Biomed Opt. 2017 Oct;22(10):1-6. doi: 10.1117/1.JBO.22.10.106003.
3
Functional imaging of cerebrovascular activities in small animals using high-resolution photoacoustic tomography.
Med Phys. 2007 Aug;34(8):3294-301. doi: 10.1118/1.2757088.
4
Dynamic in vivo imaging of small animal brain using pulsed laser diode-based photoacoustic tomography system.
J Biomed Opt. 2017 Sep;22(9):1-4. doi: 10.1117/1.JBO.22.9.090501.
5
Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography.
Nanotechnology. 2009 Sep 30;20(39):395102. doi: 10.1088/0957-4484/20/39/395102. Epub 2009 Sep 3.
6
Methylene blue microbubbles as a model dual-modality contrast agent for ultrasound and activatable photoacoustic imaging.
J Biomed Opt. 2014 Jan;19(1):16005. doi: 10.1117/1.JBO.19.1.016005.
7
Cross-Ray Ultrasound Tomography and Photoacoustic Tomography of Cerebral Hemodynamics in Rodents.
Adv Sci (Weinh). 2022 Sep;9(25):e2201104. doi: 10.1002/advs.202201104. Epub 2022 Jul 11.
8
Photoacoustic tomography of a rat cerebral cortex in vivo with au nanocages as an optical contrast agent.
Nano Lett. 2007 Dec;7(12):3798-802. doi: 10.1021/nl072349r. Epub 2007 Nov 20.
9
Hybrid Photoacoustic/Ultrasound Tomograph for Real-Time Finger Imaging.
Ultrasound Med Biol. 2017 Oct;43(10):2200-2212. doi: 10.1016/j.ultrasmedbio.2017.05.015. Epub 2017 Jun 29.
10
Acoustically penetrable optical reflector for photoacoustic tomography.
J Biomed Opt. 2013 Jul;18(7):070503. doi: 10.1117/1.JBO.18.7.070503.
引用本文的文献
1
Ultrasound-assisted aberration correction of transcranial photoacoustic imaging based on angular spectrum theory.
Photoacoustics. 2024 Nov 9;40:100665. doi: 10.1016/j.pacs.2024.100665. eCollection 2024 Dec.
2
Influence mechanism of the temporal duration of laser irradiation on photoacoustic technique: a review.
J Biomed Opt. 2024 Jan;29(Suppl 1):S11530. doi: 10.1117/1.JBO.29.S1.S11530. Epub 2024 Apr 17.
3
Spiral laser scanning photoacoustic microscopy for functional brain imaging in rats.
Neurophotonics. 2024 Jan;11(1):015007. doi: 10.1117/1.NPh.11.1.015007. Epub 2024 Feb 9.
4
Android mobile-platform-based image reconstruction for photoacoustic tomography.
J Biomed Opt. 2023 Apr;28(4):046009. doi: 10.1117/1.JBO.28.4.046009. Epub 2023 Apr 27.
5
High frame rate (∼3 Hz) circular photoacoustic tomography using single-element ultrasound transducer aided with deep learning.
J Biomed Opt. 2022 Jun;27(6):066005. doi: 10.1117/1.JBO.27.6.066005. Epub 2022 Jun 20.
6
Contrast Agents for Photoacoustic Imaging: A Review Focusing on the Wavelength Range.
Biosensors (Basel). 2022 Aug 3;12(8):594. doi: 10.3390/bios12080594.
7
Photoacoustic Imaging in Biomedicine and Life Sciences.
Life (Basel). 2022 Apr 14;12(4):588. doi: 10.3390/life12040588.
8
Design Principles Governing the Development of Theranostic Anticancer Agents and Their Nanoformulations with Photoacoustic Properties.
Pharmaceutics. 2022 Feb 4;14(2):362. doi: 10.3390/pharmaceutics14020362.
9
Technical considerations in the Verasonics research ultrasound platform for developing a photoacoustic imaging system.
Biomed Opt Express. 2021 Jan 27;12(2):1050-1084. doi: 10.1364/BOE.415481. eCollection 2021 Feb 1.
10
Spherical-view photoacoustic tomography for monitoring placental function.
Photoacoustics. 2020 Sep 29;20:100209. doi: 10.1016/j.pacs.2020.100209. eCollection 2020 Dec.
本文引用的文献
1
Multiscale photoacoustic microscopy and computed tomography.
Nat Photonics. 2009 Aug 29;3(9):503-509. doi: 10.1038/nphoton.2009.157.
2
Photoacoustic tomography and sensing in biomedicine.
Phys Med Biol. 2009 Oct 7;54(19):R59-97. doi: 10.1088/0031-9155/54/19/R01. Epub 2009 Sep 1.
3
Noninvasive, in vivo imaging of the mouse brain using photoacoustic microscopy.
J Appl Phys. 2009 May 15;105(10):102027. doi: 10.1063/1.3116134. Epub 2009 May 19.
4
Fast full-view photoacoustic imaging by combined scanning with a linear transducer array.
Opt Express. 2007 Nov 12;15(23):15566-75. doi: 10.1364/oe.15.015566.
5
A real-time photoacoustic tomography system for small animals.
Opt Express. 2009 Jun 22;17(13):10489-98. doi: 10.1364/oe.17.010489.
6
Mapping of cerebro-vascular blood perfusion in mice with skin and skull intact by Optical Micro-AngioGraphy at 1.3 mum wavelength.
Opt Express. 2007 Sep 3;15(18):11402-12. doi: 10.1364/oe.15.011402.
7
Three-dimensional noninvasive imaging of the vasculature in the mouse brain using a high resolution photoacoustic scanner.
Appl Opt. 2009 Apr 1;48(10):D299-306. doi: 10.1364/ao.48.00d299.
8
The application of compressed sensing for photo-acoustic tomography.
IEEE Trans Med Imaging. 2009 Apr;28(4):585-94. doi: 10.1109/TMI.2008.2007825. Epub 2008 Oct 31.
9
Functional imaging of cerebrovascular activities in small animals using high-resolution photoacoustic tomography.
Med Phys. 2007 Aug;34(8):3294-301. doi: 10.1118/1.2757088.
10
Universal back-projection algorithm for photoacoustic computed tomography.
Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Jan;71(1 Pt 2):016706. doi: 10.1103/PhysRevE.71.016706. Epub 2005 Jan 19.
Zotero 插件