J Biomed Opt. 2010 Jan-Feb;15(1):010509. doi: 10.1117/1.3302807.
For the first time, the hemodynamics within the entire cerebral cortex of a mouse were studied by using photoacoustic tomography (PAT) in real time. The PAT system, based on a 512-element full-ring ultrasound array, received photoacoustic signals primarily from a slice of 2-mm thickness. This system can provide high-resolution brain vasculature images. We also monitored the fast wash-in process of a photoacoustic contrast agent in the mouse brain. Our results demonstrated that PAT is a powerful imaging modality that can be potentially used to study small animal neurofunctional activities.
首次通过光声断层扫描（PAT）实时研究了小鼠整个大脑皮层内的血液动力学。该 PAT 系统基于 512 个单元的全环超声阵列，主要从 2 毫米厚的切片接收光声信号。该系统可以提供高分辨率的大脑血管图像。我们还监测了光声对比剂在小鼠大脑中的快速灌注过程。我们的结果表明，PAT 是一种强大的成像方式，可用于研究小动物的神经功能活动。
