多功能微泡和纳米泡用于光声和超声成像。
Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging.
出版信息
J Biomed Opt. 2010 Jan-Feb;15(1):010510. doi: 10.1117/1.3302808.
Abstract
We develop a novel dual-modal contrast agent-encapsulated-ink poly(lactic-co-glycolic acid) (PLGA) microbubbles and nanobubbles-for photoacoustic and ultrasound imaging. Soft gelatin phantoms with embedded tumor simulators of encapsulated-ink PLGA microbubbles and nanobubbles in various concentrations are clearly shown in both photoacoustic and ultrasound images. In addition, using photoacoustic imaging, we successfully image the samples positioned below 1.8-cm-thick chicken breast tissues. Potentially, simultaneous photoacoustic and ultrasound imaging enhanced by encapsulated-dye PLGA microbubbles or nanobubbles can be a valuable tool for intraoperative assessment of tumor boundaries and therapeutic margins.
摘要
我们开发了一种新型的双模态对比剂封装墨水聚乳酸-共-羟基乙酸（PLGA）微泡和纳米泡，用于光声和超声成像。软明胶体模中嵌入了浓度不同的封装墨水 PLGA 微泡和纳米泡的肿瘤模拟物，在光声和超声图像中均清晰可见。此外，我们还成功地使用光声成像对置于 1.8 厘米厚的鸡胸组织下方的样本进行了成像。通过封装染料 PLGA 微泡或纳米泡增强的同时进行光声和超声成像，可能成为术中评估肿瘤边界和治疗边界的一种有价值的工具。
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