PRDM9 以锌指指向减数分裂重组热点。
PRDM9 points the zinc finger at meiotic recombination hotspots.
机构信息
MRC Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK.
出版信息
Genome Biol. 2010;11(2):104. doi: 10.1186/gb-2010-11-2-104. Epub 2010 Feb 26.
Abstract
Meiotic recombination events are spread nonrandomly across eukaryotic genomes in 'hotspots'. Recent work shows that a unique histone methyltransferase, PRDM9, determines their distribution.
摘要
减数分裂重组事件在真核生物基因组中“热点”处呈非随机分布。最近的研究表明，一种独特的组蛋白甲基转移酶 PRDM9 决定了它们的分布。
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本文引用的文献
1
Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination.在灵长类动物中消除热点基序表明 PRDM9 基因参与减数分裂重组。
Science. 2010 Feb 12;327(5967):876-9. doi: 10.1126/science.1182363. Epub 2009 Dec 31.
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PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice.PRDM9 是人类和小鼠减数分裂重组热点的主要决定因素。
Science. 2010 Feb 12;327(5967):836-40. doi: 10.1126/science.1183439. Epub 2009 Dec 31.
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Prdm9 controls activation of mammalian recombination hotspots.PRDM9 控制着哺乳动物重组热点的激活。
Science. 2010 Feb 12;327(5967):835. doi: 10.1126/science.1181495. Epub 2009 Dec 31.
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Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa.Prdm9 种系基因在不同后生动物类群中的加速进化。
PLoS Genet. 2009 Dec;5(12):e1000753. doi: 10.1371/journal.pgen.1000753. Epub 2009 Dec 4.
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Distinct histone modifications define initiation and repair of meiotic recombination in the mouse.不同的组蛋白修饰决定了小鼠减数分裂重组的起始和修复。
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A common sequence motif associated with recombination hot spots and genome instability in humans.一种与人类重组热点和基因组不稳定性相关的常见序列基序。
Nat Genet. 2008 Sep;40(9):1124-9. doi: 10.1038/ng.213.
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EMBO J. 2009 Jan 21;28(2):99-111. doi: 10.1038/emboj.2008.257. Epub 2008 Dec 11.
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