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Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination.
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Mouse PRDM9 DNA-binding specificity determines sites of histone H3 lysine 4 trimethylation for initiation of meiotic recombination.
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Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice.
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The long zinc finger domain of PRDM9 forms a highly stable and long-lived complex with its DNA recognition sequence.
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Ruminant-specific multiple duplication events of PRDM9 before speciation.
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Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation.
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本文引用的文献
1
Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination.
Science. 2010 Feb 12;327(5967):876-9. doi: 10.1126/science.1182363. Epub 2009 Dec 31.
2
PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice.
Science. 2010 Feb 12;327(5967):836-40. doi: 10.1126/science.1183439. Epub 2009 Dec 31.
3
Prdm9 controls activation of mammalian recombination hotspots.
Science. 2010 Feb 12;327(5967):835. doi: 10.1126/science.1181495. Epub 2009 Dec 31.
4
Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa.
PLoS Genet. 2009 Dec;5(12):e1000753. doi: 10.1371/journal.pgen.1000753. Epub 2009 Dec 4.
5
Distinct histone modifications define initiation and repair of meiotic recombination in the mouse.
EMBO J. 2009 Sep 2;28(17):2616-24. doi: 10.1038/emboj.2009.207. Epub 2009 Jul 30.
6
A common sequence motif associated with recombination hot spots and genome instability in humans.
Nat Genet. 2008 Sep;40(9):1124-9. doi: 10.1038/ng.213.
7
Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites.
EMBO J. 2009 Jan 21;28(2):99-111. doi: 10.1038/emboj.2008.257. Epub 2008 Dec 11.
8
Probing meiotic recombination decisions.
Dev Cell. 2008 Sep;15(3):331-332. doi: 10.1016/j.devcel.2008.08.009.
9
A histone H3 methyltransferase controls epigenetic events required for meiotic prophase.
Nature. 2005 Nov 17;438(7066):374-8. doi: 10.1038/nature04112.
10
A fine-scale map of recombination rates and hotspots across the human genome.
Science. 2005 Oct 14;310(5746):321-4. doi: 10.1126/science.1117196.
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