清醒患者喉部的光学相干断层扫描
Optical coherence tomography of the larynx in the awake patient.
作者信息
Sepehr Ali, Armstrong William B, Guo Shuguang, Su Jianping, Perez Jorge, Chen Zhonping, Wong Brian J F
机构信息
Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA.
出版信息
Otolaryngol Head Neck Surg. 2008 Apr;138(4):425-9. doi: 10.1016/j.otohns.2007.12.005.
OBJECTIVE
To demonstrate the feasibility of performing optical coherence tomography of the human larynx on the awake patient with a novel flexible fiberoptic delivery system.
STUDY DESIGN
Prospective clinical trial.
SUBJECTS AND METHODS
Imaging was performed in 17 awake patients. A flexible optical coherence tomography probe was inserted through the nose and placed in near or gentle contact with laryngeal tissues under direct endoscopic visualization.
RESULTS
Images were successfully obtained from all laryngeal subsites and clearly identified laryngeal mucosal microanatomy. Several critical probe design modifications improved rotational and angular control of the distal tip while allowing linear translation of the probe and allowing more accurate apposition of the probe onto target tissues, which is critical for transnasal laryngeal imaging.
CONCLUSION
This study demonstrates the feasibility of awake transnasal laryngeal optical coherence tomography and identifies key instrumentation needed to obtain useful images.
目的
利用一种新型柔性光纤传输系统，证明在清醒患者身上进行人喉光学相干断层扫描的可行性。
研究设计
前瞻性临床试验。
研究对象与方法
对17名清醒患者进行成像。将一个柔性光学相干断层扫描探头经鼻插入，在直接内镜可视化下放置于与喉组织接近或轻柔接触的位置。
结果
成功从所有喉亚部位获取图像，并清晰识别喉黏膜微观解剖结构。探头设计的几项关键改进提高了远端尖端的旋转和角度控制，同时允许探头进行线性平移，并能更准确地将探头贴附到目标组织上，这对于经鼻喉成像至关重要。
结论
本研究证明了清醒经鼻喉光学相干断层扫描的可行性，并确定了获取有用图像所需的关键器械。
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