Tsai Meng-Tsan, Lee Hsiang-Chieh, Lu Chih-Wei, Wang Yih-Ming, Lee Cheng-Kuang, Yang C C, Chiang Chun-Ping
National Taiwan University, Institute of Photonics and Optoelectronics, Department of Electrical Engineering, 1 Roosevelt Road, Section 4, Taipei, Taiwan.
J Biomed Opt. 2008 Jul-Aug;13(4):044012. doi: 10.1117/1.2960632.
We demonstrate the ex vivo imaging of an oral cancerous sample with a swept-source optical coherence tomography (SS-OCT) system. With the axial resolution of 8 microm in free space and system sensitivity of 108 dB, we can well distinguish the normal and abnormal tissue portions in a sample. In particular, we analyze the lateral variation of A-scan profiles to show two parameters of SS-OCT signal for delineating an oral cancer lesion. One of the parameters is the decay constant in the exponential fitting of the SS-OCT signal intensity along depth. This decay constant decreases as the A-scan point moves laterally across the margin of a lesion. The other parameter is the standard deviation of the SS-OCT signal intensity fluctuation in an A-scan. This parameter increases significantly when the A-scan point is moved across the transition region between the normal and abnormal portions. Such parameters are useful for determining the margins of oral cancer.
我们展示了使用扫频光学相干断层扫描（SS - OCT）系统对口腔癌样本进行离体成像。该系统在自由空间中的轴向分辨率为8微米，系统灵敏度为108分贝，我们能够很好地区分样本中的正常组织部分和异常组织部分。特别是，我们分析了A扫描剖面图的横向变化，以展示用于描绘口腔癌病变的SS - OCT信号的两个参数。其中一个参数是SS - OCT信号强度沿深度的指数拟合中的衰减常数。当A扫描点横向穿过病变边缘时，这个衰减常数会减小。另一个参数是A扫描中SS - OCT信号强度波动的标准差。当A扫描点穿过正常部分和异常部分之间的过渡区域时，这个参数会显著增加。这些参数对于确定口腔癌的边缘很有用。
