Handler A, Kistin N, Davis F, Ferré C
School of Public Health, University of Illinois, Chicago 60680.
Am J Epidemiol. 1991 Apr 15;133(8):818-25. doi: 10.1093/oxfordjournals.aje.a115961.
The relation between maternal cocaine use and perinatal outcomes was investigated among 17,466 non-Asian singleton deliveries in 1988 from the University of Illinois Perinatal Network data base in the metropolitan Chicago area. Elevated adjusted relative risks (RR) of low birth weight (RR = 2.8, 95% confidence interval (CI) 2.2-3.7), prematurity (RR = 2.4, 95% CI 1.9-3.1), abruptio placentae (RR = 4.5, 95% CI 2.4-8.5), and perinatal death (RR = 2.1, 95% CI 1.1-4.0) were observed for "any" cocaine users (n = 408) compared with women who did not use cocaine or any other drugs or alcohol (n = 17,058). There was an increased (although unstable) risk of intrapartum placenta previa not previously reported (RR = 2.3, 95% CI 1.0-5.1). The relative risk of small-for-gestational-age births for cocaine users who did not smoke (RR = 3.4, 95% CI 1.8-6.5) was greater than that for cocaine users who did (RR = 2.1, 95% CI 1.1-4.1). Irrespective of smoking status, cocaine use during pregnancy increased the risk of small-for-gestational-age births.
利用伊利诺伊大学围产期网络数据库中1988年芝加哥市区17466例非亚裔单胎分娩的数据，研究了孕妇使用可卡因与围产期结局之间的关系。与未使用可卡因、其他药物或酒精的女性（n = 17058）相比，“任何”可卡因使用者（n = 408）出现低出生体重（相对危险度（RR）= 2.8，95%可信区间（CI）2.2 - 3.7）、早产（RR = 2.4，95% CI 1.9 - 3.1）、胎盘早剥（RR = 4.5，95% CI 2.4 - 8.5）和围产期死亡（RR = 2.1，95% CI 1.1 - 4.0）的校正相对危险度升高。有一项此前未报告的产时前置胎盘风险增加（尽管不稳定）（RR = 2.3，95% CI 1.0 - 5.1）。不吸烟的可卡因使用者发生小于胎龄儿出生的相对危险度（RR = 3.4，95% CI 1.8 - 6.5）高于吸烟的可卡因使用者（RR = 2.1，95% CI 1.1 - 4.1）。无论吸烟状况如何，孕期使用可卡因都会增加小于胎龄儿出生的风险。
