Department of Electrical Engineering, Centre of Technological Science, University of Santa Catarina State (UDESC), Joinville, Santa Catarina, Brazil.
Med Biol Eng Comput. 2010 Apr;48(4):311-9. doi: 10.1007/s11517-010-0591-4. Epub 2010 Mar 6.
This article presents an efficient numerical approach to simulate the process of polarization and ion conduction in membranes of biological cells subjected to intense electric fields. The proposed method uses Coulomb's law to calculate the electric field on the surface of the cell membrane and the continuity equation for calculating the difference in electric potential between the faces of the membrane. The behavior of the membrane conductance is described by a model of electroporation proposed in literature. This method provides results that agree well with the analytical model of polarization of an isolated cell suspended in electrolytic solution and also provides results for the conductance of the membrane during electroporation of cells in concentrated suspensions that agree with experimental results already published.
本文提出了一种高效的数值方法，用于模拟在强电场作用下生物细胞膜的极化和离子传导过程。该方法使用库仑定律计算细胞膜表面的电场，以及连续方程计算膜两面之间的电势差。膜电导的行为由文献中提出的电穿孔模型来描述。该方法提供的结果与悬浮在电解质溶液中的孤立细胞的极化分析模型吻合较好，并且对于细胞在浓缩悬浮液中的电穿孔过程中的膜电导提供的结果与已经发表的实验结果吻合较好。
