母亲妊娠期糖尿病暴露的青少年葡萄糖耐量受损和心脏代谢风险：一项 15 年随访研究。
Glucose intolerance and cardiometabolic risk in adolescents exposed to maternal gestational diabetes: a 15-year follow-up study.
机构信息
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR.
出版信息
Diabetes Care. 2010 Jun;33(6):1382-4. doi: 10.2337/dc09-2343. Epub 2010 Mar 9.
Abstract
OBJECTIVE
Adolescent offspring of women with a history of gestational diabetes (GD) were evaluated for their cardiometabolic risks at a mean age of 15 years.
RESEARCH DESIGN AND METHODS
One hundred and twenty-nine adolescents who were assessed for their cardiometabolic risks at 8 years of age were reassessed at 15 years of age.
RESULTS
Adolescent offspring of mothers with GD had similar blood pressure, plasma lipid profile, and a rate of abnormal glucose tolerance as control subjects. In utero hyperinsulinemia was associated with a 17-fold increase in metabolic syndrome and a 10-fold increase in overweight at adolescence, independent of birth weight, Tanner stage, maternal GD status, and mother's BMI.
CONCLUSIONS
In utero environment of hyperinsulinemia, irrespective of the degree of maternal GD, was associated with increased risk of overweight and metabolic syndrome during early adolescence in the offspring.
摘要
目的
对有妊娠糖尿病（GD）病史的女性的青少年后代进行评估，以了解其在平均 15 岁时的心血管代谢风险。
研究设计和方法
对 129 名在 8 岁时评估过心血管代谢风险的青少年进行了重新评估。
结果
母亲患有 GD 的青少年后代的血压、血浆脂质谱和异常葡萄糖耐量的发生率与对照组相似。宫内高胰岛素血症与青少年时期代谢综合征的发生风险增加 17 倍以及超重的发生风险增加 10 倍相关，这与出生体重、性发育分期、母亲 GD 状态和母亲 BMI 无关。
结论
无论母亲 GD 的严重程度如何，宫内高胰岛素血症环境与后代在青少年早期超重和代谢综合征风险增加有关。
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