年龄对胃癌生长和扩散的影响。
The influence of age on the growth and spread of gastric carcinoma.
作者信息
Janssen C W, Lie R T, Maartmann-Moe H, Matre R
机构信息
Department of Surgery, Gade Institute, University of Bergen, Norway.
出版信息
Br J Cancer. 1991 Apr;63(4):623-5. doi: 10.1038/bjc.1991.142.
A twelve year series of 375 patients with gastric carcinoma has been studied. Patients were divided into TNM Groups. Tumours were classified as intestinal-type and diffuse. The patients with T1-3NOMO diffuse tumour were ten years younger than the patients with T1-3NOMO intestinal-type tumour. The mean age increased from T1 through T2 to those with T3 tumour. The age differences between the T-stages were the same in both groups, which indicate that once started, the diffuse and the intestinal-type tumours infiltrate the gastric wall at about the same rate. Among the patients with intestinal-type tumour, those with lymph node or distant metastases were three to seven years younger than the patients without metastases. On the other hand, the patients with diffuse tumour and metastases were as many years older than the patients without metastases. Apparently, tumour spread is age dependent and different between the two types of gastric carcinoma. The ill repute of the diffuse gastric carcinoma may therefore be explained by the advanced stage of that tumour at the time of treatment as compared to the intestinal-type tumour. The diffuse tumour seems to be clinically more silent and to give symptoms at a later stage than the intestinal-type tumour.
对375例胃癌患者进行了为期12年的研究。患者被分为TNM组。肿瘤分为肠型和弥漫型。T1 - 3N0M0弥漫型肿瘤患者比T1 - 3N0M0肠型肿瘤患者年轻10岁。平均年龄从T1期到T2期再到T3期肿瘤患者逐渐增加。两组T分期之间的年龄差异相同，这表明一旦开始，弥漫型和肠型肿瘤以大致相同的速率浸润胃壁。在肠型肿瘤患者中，有淋巴结或远处转移的患者比无转移的患者年轻3至7岁。另一方面，有弥漫型肿瘤和转移的患者比无转移的患者年龄大很多。显然，肿瘤扩散与年龄有关，且在两种类型的胃癌中有所不同。因此，弥漫型胃癌声名狼藉的原因可能是与肠型肿瘤相比，该肿瘤在治疗时处于晚期。弥漫型肿瘤在临床上似乎更隐匿，比肠型肿瘤出现症状的时间更晚。
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