Department of Pharmacology, Indian Institute of Integrative Medicine, Jammu Tawi, India.
Planta Med. 2010 Oct;76(14):1497-505. doi: 10.1055/s-0029-1240953. Epub 2010 Mar 9.
The aim of the present study was to investigate the antistress potential of LABISIA PUMILA aqueous extract (LPPM/A003) using a battery of tests widely employed in different stressful situations. Pretreatment of experimental animals with LPPM/A003 caused an increase in the swimming endurance and hypoxia time and also showed the recovery of physical stress-induced depletion of neuromuscular coordination and scopolamine induced memory deficit. LPPM/A003 at graded doses reversed the chronic restraint stress (RST), induced depletion of CD4 (+) and CD8 (+) T lymphocytes, NK cell population, and corresponding cytokines expression besides downregulating the stress-induced increase in plasma corticosterone, a major stress hormone. In addition, LPPM/A003 reversed the chronic stress-induced increase in adrenal gland weight, serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), and hepatic lipid peroxidation (LP) levels and augmented the RST induced decrease in hepatic glutathione (GSH), thymus and spleen weight. Thus, we conclude that LPPM/A003 has the ability to reverse the alterations produced by various stressful stimuli and therefore restores homeostasis.
本研究旨在利用广泛应用于不同应激情况的一系列测试来研究 LABISIA PUMILA 水提物（LPPM/A003）的抗应激潜力。实验动物用 LPPM/A003 预处理可增加游泳耐力和耐缺氧时间，并可恢复因体力应激导致的神经肌肉协调功能下降和东莨菪碱诱导的记忆缺陷。LPPM/A003 以不同剂量给药可逆转慢性束缚应激（RST），诱导 CD4(+)和 CD8(+)T 淋巴细胞、NK 细胞群以及相应细胞因子表达减少，同时降低应激诱导的血浆皮质酮（一种主要的应激激素）增加。此外，LPPM/A003 逆转了慢性应激诱导的肾上腺重量、血清丙氨酸氨基转移酶（ALT）、碱性磷酸酶（ALP）和肝脏脂质过氧化（LP）水平的增加，并增强了 RST 诱导的肝脏谷胱甘肽（GSH）、胸腺和脾脏重量的减少。因此，我们得出结论，LPPM/A003 具有逆转各种应激刺激产生的变化的能力，从而恢复体内平衡。
