A review of the applications of physiologically based pharmacokinetic modeling.

The physiological pharmacokinetic approach to the modeling of drug distribution is reviewed. These models allow extrapolation outside the range of data with some confidence if the dominant mechanisms of transport are sufficiently well understood. In addition, it is possible to extrapolate to other species. Compartments correspond to anatomical spaces so that biochemical interactions (including drug effect or pharmacodynamics) can be incorporated in the model. The articles summarized in this review are limited to models dealing with drug application.