开放和闭环胰岛素输送系统的未来。
The future of open- and closed-loop insulin delivery systems.
作者信息
Farmer Terry G, Edgar Thomas F, Peppas Nicholas A
机构信息
Department of Chemical Engineering, The University of Texas at Austin, 1 University Station C0400, Austin, TX 78712-0231, USA.
出版信息
J Pharm Pharmacol. 2008 Jan;60(1):1-13. doi: 10.1211/jpp.60.1.0001.
Abstract
We have analysed several aspects of insulin-dependent diabetes mellitus, including the glucose metabolic system, diabetes complications, and previous and ongoing research aimed at controlling glucose in diabetic patients. An expert review of various models and control algorithms developed for the glucose homeostasis system is presented, along with an analysis of research towards the development of a polymeric insulin infusion system. Recommendations for future directions in creating a true closed-loop glucose control system are presented, including the development of multivariable models and control systems to more accurately describe and control the multi-metabolite, multi-hormonal system, as well as in-vivo assessments of implicit closed-loop control systems.
摘要
我们分析了胰岛素依赖型糖尿病的几个方面，包括葡萄糖代谢系统、糖尿病并发症，以及以往和正在进行的旨在控制糖尿病患者血糖的研究。本文对为葡萄糖稳态系统开发的各种模型和控制算法进行了专家综述，并分析了聚合物胰岛素输注系统的研发情况。文中还提出了创建真正闭环血糖控制系统的未来方向建议，包括开发多变量模型和控制系统，以更准确地描述和控制多代谢物、多激素系统，以及对隐式闭环控制系统进行体内评估。
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本文引用的文献
1
A review of the applications of physiologically based pharmacokinetic modeling.基于生理的药代动力学建模应用综述。
J Pharmacokinet Biopharm. 1979 Apr;7(2):127-45. doi: 10.1007/BF01059734.
2
Adaptive closed-loop control provides blood-glucose regulation using dual subcutaneous insulin and glucagon infusion in diabetic Swine.自适应闭环控制通过在糖尿病猪中进行皮下胰岛素和胰高血糖素双重输注来实现血糖调节。
J Diabetes Sci Technol. 2007 Mar;1(2):181-92. doi: 10.1177/193229680700100208.
3
Inhaled insulin for diabetes mellitus.用于糖尿病的吸入式胰岛素。
N Engl J Med. 2007 Feb 1;356(5):497-502. doi: 10.1056/NEJMct063533.
4
Dynamic modeling of free fatty acid, glucose, and insulin: an extended "minimal model".游离脂肪酸、葡萄糖和胰岛素的动态建模：一个扩展的“最小模型”。
Diabetes Technol Ther. 2006 Dec;8(6):617-26. doi: 10.1089/dia.2006.8.617.
5
Is the oral route possible for peptide and protein drug delivery?肽和蛋白质药物递送采用口服途径可行吗？
Drug Discov Today. 2006 Oct;11(19-20):905-10. doi: 10.1016/j.drudis.2006.08.005. Epub 2006 Sep 7.
6
Two-hour seven-sample oral glucose tolerance test and meal protocol: minimal model assessment of beta-cell responsivity and insulin sensitivity in nondiabetic individuals.两小时七样本口服葡萄糖耐量试验及进餐方案：非糖尿病个体β细胞反应性和胰岛素敏感性的最小模型评估
Diabetes. 2005 Nov;54(11):3265-73. doi: 10.2337/diabetes.54.11.3265.
7
Regulation of pancreatic beta-cell mass.胰腺β细胞质量的调节。
Physiol Rev. 2005 Oct;85(4):1255-70. doi: 10.1152/physrev.00025.2004.
8
Insulin control of glucose metabolism in man: a new kinetic analysis.胰岛素对人体葡萄糖代谢的控制：一项新的动力学分析。
J Clin Invest. 1975 May;55(5):1057-66. doi: 10.1172/JCI108006.
9
Modeling insulin action for development of a closed-loop artificial pancreas.用于闭环人工胰腺开发的胰岛素作用建模。
Diabetes Technol Ther. 2005 Feb;7(1):94-108. doi: 10.1089/dia.2005.7.94.
10
Pharmacokinetics of intravenous insulin delivery in humans with type 1 diabetes.1型糖尿病患者静脉注射胰岛素的药代动力学
Diabetes Technol Ther. 2005 Feb;7(1):83-93. doi: 10.1089/dia.2005.7.83.
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