开放和闭环胰岛素输送系统的未来。
The future of open- and closed-loop insulin delivery systems.
作者信息
Farmer Terry G, Edgar Thomas F, Peppas Nicholas A
机构信息
Department of Chemical Engineering, The University of Texas at Austin, 1 University Station C0400, Austin, TX 78712-0231, USA.
出版信息
J Pharm Pharmacol. 2008 Jan;60(1):1-13. doi: 10.1211/jpp.60.1.0001.
Abstract
We have analysed several aspects of insulin-dependent diabetes mellitus, including the glucose metabolic system, diabetes complications, and previous and ongoing research aimed at controlling glucose in diabetic patients. An expert review of various models and control algorithms developed for the glucose homeostasis system is presented, along with an analysis of research towards the development of a polymeric insulin infusion system. Recommendations for future directions in creating a true closed-loop glucose control system are presented, including the development of multivariable models and control systems to more accurately describe and control the multi-metabolite, multi-hormonal system, as well as in-vivo assessments of implicit closed-loop control systems.
摘要
我们分析了胰岛素依赖型糖尿病的几个方面，包括葡萄糖代谢系统、糖尿病并发症，以及以往和正在进行的旨在控制糖尿病患者血糖的研究。本文对为葡萄糖稳态系统开发的各种模型和控制算法进行了专家综述，并分析了聚合物胰岛素输注系统的研发情况。文中还提出了创建真正闭环血糖控制系统的未来方向建议，包括开发多变量模型和控制系统，以更准确地描述和控制多代谢物、多激素系统，以及对隐式闭环控制系统进行体内评估。
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