Centre for Nanostructured Media, IRCEP, Queen's University of Belfast, BT71NN, United Kingdom.
ACS Nano. 2010 Apr 27;4(4):2210-6. doi: 10.1021/nn9015828.
We show that aligned gold nanotube arrays capable of supporting plasmonic resonances can be used as high performance refractive index sensors in biomolecular binding reactions. A methodology to examine the sensing ability of the inside and outside walls of the nanotube structures is presented. The sensitivity of the plasmonic nanotubes is found to increase as the nanotube walls are exposed, and the sensing characteristic of the inside and outside walls is shown to be different. Finite element simulations showed good qualitative agreement with the observed behavior. Free standing gold nanotubes displayed bulk sensitivities in the region of 250 nm per refractive index unit and a signal-to-noise ratio better than 1000 upon protein binding which is highly competitive with state-of-the-art label-free sensors.
我们表明，排列整齐的金纳米管阵列能够支持等离子体共振，可用于生物分子结合反应中的高性能折射率传感器。本文提出了一种检查纳米管结构内外壁传感能力的方法。研究发现，随着纳米管壁的暴露，等离子体纳米管的灵敏度增加，并且内外壁的传感特性表现出不同。有限元模拟与观察到的行为具有很好的定性一致性。自由站立的金纳米管在折射率单位为 250nm 时表现出体灵敏度，并且在蛋白质结合时的信噪比优于 1000，这与最先进的无标记传感器具有很强的竞争力。
