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非酯化脂肪酸在调节血浆胆固醇转运中的作用。

Role of non-esterified fatty acids in regulating plasma cholesterol transport.

作者信息

Barter P J

机构信息

Baker Medical Research Institute, Prahran, Victoria, Australia.

出版信息

Clin Exp Pharmacol Physiol. 1991 Feb;18(2):77-9. doi: 10.1111/j.1440-1681.1991.tb01410.x.

DOI:10.1111/j.1440-1681.1991.tb01410.x
PMID:2022079
Abstract
  1. The cholesteryl ester transfer protein (CETP) promotes an equimolar exchange of cholesteryl esters between the high density lipoproteins (HDL) and low density lipoproteins (LDL) in human plasma. 2. Sodium oleate converts this CETP-mediated process of exchange into one of net mass transfer of cholesteryl esters from HDL to LDL. 3. Thus, conditions which increase the concentration of non-esterified fatty acids in plasma may favour the redistribution of cholesterol from the non-atherogenic HDL to the atherogenic LDL fraction.
摘要
  1. 胆固醇酯转运蛋白(CETP)促进人血浆中高密度脂蛋白(HDL)和低密度脂蛋白(LDL)之间胆固醇酯的等摩尔交换。2. 油酸钠将这种由CETP介导的交换过程转变为胆固醇酯从HDL到LDL的净质量转移过程。3. 因此,增加血浆中非酯化脂肪酸浓度的条件可能有利于胆固醇从抗动脉粥样硬化的HDL向致动脉粥样硬化的LDL组分重新分布。

相似文献

1
Role of non-esterified fatty acids in regulating plasma cholesterol transport.非酯化脂肪酸在调节血浆胆固醇转运中的作用。
Clin Exp Pharmacol Physiol. 1991 Feb;18(2):77-9. doi: 10.1111/j.1440-1681.1991.tb01410.x.
2
Effects of various non-esterified fatty acids on the transfer of cholesteryl esters from HDL to LDL induced by the cholesteryl ester transfer protein.各种非酯化脂肪酸对胆固醇酯转移蛋白诱导的胆固醇酯从高密度脂蛋白向低密度脂蛋白转移的影响。
Biochim Biophys Acta. 1991 Sep 11;1085(2):209-16. doi: 10.1016/0005-2760(91)90096-z.
3
Evidence for nonesterified fatty acids as modulators of neutral lipid transfers in normolipidemic human plasma.非酯化脂肪酸作为正常血脂水平人血浆中中性脂质转运调节因子的证据。
Arterioscler Thromb Vasc Biol. 1995 Sep;15(9):1388-96. doi: 10.1161/01.atv.15.9.1388.
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Familial cholesteryl ester transfer protein deficiency is associated with triglyceride-rich low density lipoproteins containing cholesteryl esters of probable intracellular origin.家族性胆固醇酯转运蛋白缺乏症与富含甘油三酯的低密度脂蛋白有关,这些低密度脂蛋白含有可能源自细胞内的胆固醇酯。
J Lipid Res. 1991 Jan;32(1):21-33.
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Cholesteryl ester transfer activity in liver disease and cholestasis, and its relation with fatty acid composition of lipoprotein lipids.肝脏疾病和胆汁淤积中的胆固醇酯转移活性及其与脂蛋白脂质脂肪酸组成的关系。
Clin Chim Acta. 1996 Apr 30;248(2):157-74. doi: 10.1016/0009-8981(95)06251-3.
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Differential effects of cis and trans fatty acid isomers, oleic and elaidic acids, on the cholesteryl ester transfer protein activity.顺式和反式脂肪酸异构体、油酸和反油酸对胆固醇酯转运蛋白活性的不同影响。
Biochim Biophys Acta. 1992 Mar 4;1124(2):159-62. doi: 10.1016/0005-2760(92)90092-a.
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Modulation of the activity of the human cholesteryl ester transfer protein by carboxylated derivatives. Evidence for 13-cis-retinoic acid as a potent activator of the protein's activity in plasma.羧化衍生物对人胆固醇酯转运蛋白活性的调节。13-顺式视黄酸作为该蛋白在血浆中活性的有效激活剂的证据。
Eur J Biochem. 1996 Sep 15;240(3):699-706. doi: 10.1111/j.1432-1033.1996.0699h.x.
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Suppression of lipid transfer inhibitor protein activity by oleate. A novel mechanism of cholesteryl ester transfer protein regulation by plasma free fatty acids.油酸对脂质转运抑制蛋白活性的抑制作用。血浆游离脂肪酸调节胆固醇酯转运蛋白的一种新机制。
Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):3041-8. doi: 10.1161/01.atv.17.11.3041.
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Alterations in composition and concentration of lipoproteins and elevated cholesteryl ester transfer in non-insulin-dependent diabetes mellitus (NIDDM).非胰岛素依赖型糖尿病(NIDDM)患者脂蛋白组成和浓度的改变以及胆固醇酯转运增加。
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Mechanisms of enhanced cholesteryl ester transfer from high density lipoproteins to apolipoprotein B-containing lipoproteins during alimentary lipemia.食源性脂血症期间高密度脂蛋白中胆固醇酯向含载脂蛋白B脂蛋白转移增强的机制
J Clin Invest. 1986 Apr;77(4):1163-72. doi: 10.1172/JCI112417.

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