Dinwiddie S H, Reich T, Cloninger C R
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO.
Compr Psychiatry. 1991 Mar-Apr;32(2):133-40. doi: 10.1016/0010-440x(91)90005-w.
Intravenous drug abuse (IVDA) is a significant public health threat, and ways of identifying individuals at high risk for IVDA are needed to plan strategies for intervention and treatment. Previous work had identified similarities in psychiatric diagnosis and patterns of drug use in IVDAs and solvent users. Using the same population, we found that 59 of 179 IVDAs (33.0%) reported a history of solvent use, which preceded the onset of IVDA in 41 of the 59. IVDAs with a history of solvent use were more likely to receive diagnoses of alcoholism and antisocial personality disorder (ASP) than IVDAs without solvent use. Even allowing for these coexisting psychiatric disorders, a reported history of solvent use increased the likelihood of also reporting IVDA by a factor of 3.2. Although the magnitude of risk is likely to differ in other populations, a history of solvent use may indicate individuals at high risk for IVDA, and youths who have used solvents should be considered at high risk for severe drug abuse, including IVDA.
静脉注射吸毒是一个重大的公共卫生威胁，需要确定静脉注射吸毒高风险个体的方法，以便制定干预和治疗策略。先前的研究已经确定了静脉注射吸毒者和溶剂使用者在精神疾病诊断和吸毒模式上的相似之处。在同一人群中，我们发现179名静脉注射吸毒者中有59名（33.0%）报告有溶剂使用史，其中41名在开始静脉注射吸毒之前就有溶剂使用史。有溶剂使用史的静脉注射吸毒者比没有溶剂使用史的静脉注射吸毒者更有可能被诊断为酒精中毒和反社会人格障碍（ASP）。即使考虑到这些并存的精神疾病，报告有溶剂使用史也会使报告静脉注射吸毒的可能性增加3.2倍。尽管其他人群的风险程度可能不同，但溶剂使用史可能表明是静脉注射吸毒的高风险个体，使用过溶剂的青少年应被视为严重药物滥用（包括静脉注射吸毒）的高风险人群。
