Al-Rayyan Ehab S, Duqoum Wasef J, Sawalha Marwan S, Nascimento Marcello C, Pather Selvan, Dalrymple Christopher J, Carter Jonathan R
Sydney Gynecologic Oncology Group, Sydney Cancer Centre, Sydney, Australia.
Saudi Med J. 2009 Apr;30(4):524-8.
To review our local experience with mature cystic ovarian teratoma, and describe our treatment modality regarding this uncommon condition.
The databases of the Sydney Gynecologic Oncology Group at Royal Prince Alfred and Liverpool Hospital, Sydney, Australia, were reviewed from 1987 to 2007. A retrospective chart review, and analysis of patient's data were conducted.
Eleven cases of ovarian dermoid cyst with secondary malignancy were identified. Six out of eleven (54.5%) of the cases were carcinoid tumor, 4/11 (36%) squamous cell cancer, and one case (9%) transitional cell carcinoma. The median age of cases was 47 years (range of 28-74). Stage I-II was recorded in 8/11 (73%) of the cases, while stage III-IV was found in 3/11 (27%). The initial treatment ranged from unilateral cystectomy to hysterectomy, and bilateral salpingo-oophorectomy, and debulking surgery. All patients with stage I disease showed more than 5 years survival (100%). The survival for late staged disease (III-IV) ranged from 2.5 months to 18 months with an average of 8 months.
Carcinoid tumor is the most common malignancy noticed. Survival is related mainly to tumor stage, and optimal debulking procedure. However, further studies are needed to study the effect of other factors on survival.
回顾我们在成熟性囊性卵巢畸胎瘤方面的本地经验，并描述我们针对这种罕见病症的治疗方式。
对澳大利亚悉尼皇家阿尔弗雷德王子医院和利物浦医院悉尼妇科肿瘤学组1987年至2007年的数据库进行了回顾。进行了回顾性病历审查及患者数据分析。
确定了11例卵巢皮样囊肿伴继发性恶性肿瘤的病例。11例中的6例（54.5%）为类癌肿瘤，4/11（36%）为鳞状细胞癌，1例（9%）为移行细胞癌。病例的中位年龄为47岁（范围28 - 74岁）。8/11（73%）的病例记录为I - II期，而3/11（27%）为III - IV期。初始治疗范围从单侧囊肿切除术到子宫切除术、双侧输卵管卵巢切除术及肿瘤细胞减灭术。所有I期疾病患者均显示生存超过5年（100%）。晚期疾病（III - IV期）的生存期为2.5个月至18个月，平均为8个月。
类癌肿瘤是最常见的恶性肿瘤。生存主要与肿瘤分期及最佳肿瘤细胞减灭术有关。然而，需要进一步研究其他因素对生存的影响。
