Lakhani Muhammad Shakir, Qadir Faisal, Hanif Bashir, Farooq Salman, Khan Moinuddin
Department of Cardiology, Tabba Heart Institute, Ziauddin Medical University, Karachi, Pakistan.
J Pak Med Assoc. 2010 Mar;60(3):197-200.
To determine the correlation of thrombolysis in myocardial infarction (TIMI) risk score with extent of coronary artery disease (CAD) in patients with acute coronary syndrome (ACS).
We conducted a descriptive study among 200 consecutive patients admitted with ACS at Tabba Heart Institute, Karachi from June to December 2008. The TIMI risk score was stratified on seven standard variables. The extent of CAD was evaluated on angiography and significant CAD was defined as > or =70% stenosis in any one of the three major epicardial vessels.
The mean age of the sample was 58.53 +/- 10.64 years. Out of 200 patients, there were 142 (71%) patients with TIMI score < or =4 (low and intermediate TIMI risk score) and 58 (29%) patients with TIMI score >4 (high TIMI risk score). Patients with TIMI score >4 were more likely to have significant three vessel CAD (62%) versus those with TIMI risk score <4 (46.2%), (p < 0.04).
Patients with high TIMI risk score were more likely to have severe multivessel CAD compared with those with low or intermediate TIMI risk score. Hence, patients with TIMI score >4 should be referred for early invasive coronary evaluation to derive clinical benefit.
确定急性冠状动脉综合征（ACS）患者的心肌梗死溶栓（TIMI）风险评分与冠状动脉疾病（CAD）程度之间的相关性。
2008年6月至12月期间，我们在卡拉奇塔巴心脏研究所对200例连续入院的ACS患者进行了一项描述性研究。TIMI风险评分根据七个标准变量进行分层。通过血管造影评估CAD的程度，显著CAD定义为三大心外膜血管中任何一支血管狭窄≥70%。
样本的平均年龄为58.53±10.64岁。在200例患者中，有142例（71%）TIMI评分≤4（低和中度TIMI风险评分），58例（29%）TIMI评分>4（高TIMI风险评分）。TIMI评分>4的患者发生显著三支血管CAD的可能性更高（62%），而TIMI风险评分<4的患者为46.2%，（p<0.04）。
与低或中度TIMI风险评分的患者相比，高TIMI风险评分的患者更有可能患有严重的多支血管CAD。因此，TIMI评分>4的患者应尽早接受侵入性冠状动脉评估以获得临床益处。
