Division of Neonatology, Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA.
Am J Obstet Gynecol. 2010 Jun;202(6):544.e1-9. doi: 10.1016/j.ajog.2010.01.038. Epub 2010 Mar 15.
To compare respiratory compliance and functional residual capacity in infants randomized to a rescue course of antenatal steroids vs placebo.
Randomized, double-blinded trial. Pregnant women > or =14 days after initial antenatal steroids were randomized to rescue antenatal steroids or placebo. The primary outcomes were measurements of respiratory compliance and functional residual capacity. This study is registered with clinicaltrials.gov (NCT00669383).
Forty-four mothers (56 infants) received rescue antenatal steroids and 41 mothers (57 infants) received placebo. There was no significant difference in birthweight, or head circumference. Infants in the rescue group had an increased respiratory compliance (1.21 vs 1.01 mL/cm H(2)O/kg; adjusted 95% confidence interval, 0.01-0.49; P = .0433) compared with placebo. 13% in the rescue vs 29% in the placebo group required > or =30% oxygen (P < .05). Patients delivered at < or =34 weeks had greater pulmonary benefits.
Infants randomized to rescue antenatal steroids have a significantly increased respiratory compliance compared with placebo.
比较随机接受产前类固醇抢救疗程与安慰剂的婴儿的呼吸顺应性和功能残气量。
随机、双盲试验。对初始接受产前类固醇治疗后 > 或 =14 天的孕妇随机分配接受抢救性产前类固醇或安慰剂。主要结局是测量呼吸顺应性和功能残气量。本研究在 clinicaltrials.gov 注册(NCT00669383)。
44 位母亲(56 位婴儿)接受了抢救性产前类固醇治疗,41 位母亲(57 位婴儿)接受了安慰剂治疗。出生体重或头围无显著差异。与安慰剂组相比,抢救组的婴儿呼吸顺应性增加(1.21 比 1.01 mL/cm H2O/kg;调整后的 95%置信区间,0.01-0.49;P =.0433)。抢救组中有 13%的婴儿需要 > 或 =30%的氧气,而安慰剂组中有 29%的婴儿需要(P <.05)。在 < 或 =34 周分娩的患者有更大的肺益处。
与安慰剂相比,随机接受抢救性产前类固醇治疗的婴儿呼吸顺应性显著增加。