Division of Neonatology, Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA.
J Perinatol. 2018 Jul;38(7):828-833. doi: 10.1038/s41372-018-0124-9. Epub 2018 May 24.
To evaluate whether premature infants delivered ≤7 days after rescue antenatal steroid treatment (ideal treatment) have increased passive respiratory compliance compared to those delivered >7 days after treatment (remote treatment).
Secondary analysis of a randomized trial of rescue antenatal steroids on respiratory compliance. Infants in the treatment group were stratified by the interval between rescue antenatal steroids and delivery. We then compared the respiratory compliance in the ideal vs. remote groups.
Forty-four women (56 infants) received rescue antenatal steroids. Forty-nine infants had evaluable respiratory compliance measurements, with 27 (GA 30.1 weeks, BW 1362 g) "ideally" treated, and 22 (GA 33.8 weeks, BW 2248 g) "remotely" treated. Respiratory compliance was significantly higher for the ideal compared to the remote group (1.32 vs. 1.06 mL/cm HO/kg; p = 0.037).
Infants treated with rescue antenatal steroids have a significantly higher respiratory compliance if delivery occurs within 7 days after treatment.
评估距解救性产前皮质类固醇治疗（理想治疗）≤7 天分娩的早产儿与距治疗＞7 天分娩的早产儿（远程治疗）相比，被动呼吸顺应性是否增加。
对解救性产前皮质类固醇治疗呼吸顺应性的随机试验进行二次分析。将治疗组的婴儿按解救性产前皮质类固醇与分娩之间的间隔进行分层。然后比较理想组与远程组的呼吸顺应性。
44 名女性（56 名婴儿）接受了解救性产前皮质类固醇治疗。49 名婴儿有可评估的呼吸顺应性测量值，其中 27 名（GA 30.1 周，BW 1362g）“理想”治疗，22 名（GA 33.8 周，BW 2248g）“远程”治疗。理想组的呼吸顺应性明显高于远程组（1.32 比 1.06 mL/cm HO/kg；p=0.037）。
如果在治疗后 7 天内分娩，接受解救性产前皮质类固醇治疗的婴儿的呼吸顺应性显著更高。
