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蒙特卡罗准直器传输方法在放射治疗中的光子治疗计划比较。

Comparison of monte carlo collimator transport methods for photon treatment planning in radiotherapy.

机构信息

Division of Medical Radiation Physics, Inselspital, Berne University Hospital, and University of Berne, CH-3010 Berne, Switzerland.

出版信息

Med Phys. 2010 Feb;37(2):492-504. doi: 10.1118/1.3284978.

Abstract

PURPOSE

The aim of this work was a Monte Carlo (MC) based investigation of the impact of different radiation transport methods in collimators of a linear accelerator on photon beam characteristics, dose distributions, and efficiency. Thereby it is investigated if it is possible to use different simplifications in the radiation transport for some clinical situations in order to save calculation time.

METHODS

Within the Swiss Monte Carlo Plan, a GUI-based framework for photon MC treatment planning, different MC methods are available for the radiation transport through the collimators [secondary jaws and multileaf collimator (MLC)]: EGSnrc (reference), VMC++, and Pin (an in-house developed MC code). Additional nonfull transport methods were implemented in order to provide different complexity levels for the MC simulation: Considering collimator attenuation only, considering Compton scatter only or just the firstCompton process, and considering the collimators as totally absorbing. Furthermore, either a simple or an exact geometry of the collimators can be selected for the absorbing or attenuation method. Phasespaces directly above and dose distributions in a water phantom are analyzed for academic and clinical treatment fields using 6 and 15 MV beams, including intensity modulated radiation therapy with dynamic MLC.

RESULTS

For all MC transport methods, differences in the radial mean energy and radial energy fluence are within 1% inside the geometric field. Below the collimators, the energy fluence is underestimated for nonfull MC transport methods ranging from 5% for Compton to 100% for Absorbing. Gamma analysis using EGSnrc calculated doses as reference shows that the percentage of voxels fulfilling a 1% /1 mm criterion is at least 98% when using VMC++, Compton, or firstCompton transport methods. When using the methods Pin, Transmission, Flat-Transmission, Flat-Absorbing or Absorbing, the mean value of points fulfilling this criterion over all tested cases is 97%, 88%, 74%, 68%, or 65%, respectively. However, compared to EGSnrc calculations, the gain in efficiency is a factor of up to 10 for VMC++ and up to 48 for the absorbing method.

CONCLUSIONS

The results of this investigation suggest that it is an option to use a simple transport technique in the initial treatment planning process and use more accurate transport methods for the final dose calculation accepting longer calculation times.

摘要

目的

本研究旨在通过蒙特卡罗(MC)方法,研究不同的辐射传输方法在医用直线加速器准直器中的应用,以了解其对光子束特征、剂量分布和效率的影响。由此,我们将探讨在某些临床情况下,是否可以使用不同的简化辐射传输方法来节省计算时间。

方法

在基于图形用户界面的光子 MC 治疗计划程序 Swiss Monte Carlo Plan 中,我们提供了多种辐射传输方法来模拟准直器(次级准直器和多叶准直器(MLC))中的光子传输过程:EGSnrc(参考方法)、VMC++和 Pin(内部开发的 MC 代码)。此外,我们还实现了一些非全传输方法,以提供不同的 MC 模拟复杂度水平:仅考虑准直器衰减、仅考虑康普顿散射或仅考虑第一康普顿过程、以及将准直器视为完全吸收体。此外,我们还可以为吸收或衰减方法选择简单或精确的准直器几何形状。我们使用 6MV 和 15MV 射线,针对学术和临床治疗领域的射野,分析了直接位于准直器上方的相位空间和水模体中的剂量分布,包括使用动态 MLC 的调强放射治疗。

结果

对于所有 MC 传输方法,在几何场内部,径向平均能量和径向能量注量的差异在 1%以内。在准直器下方,非全 MC 传输方法会低估能量注量,从 Compton 方法的 5%到 Absorbing 方法的 100%不等。使用 EGSnrc 计算的剂量作为参考进行 EGSnrc 伽马分析表明,当使用 VMC++、Compton 或 firstCompton 传输方法时,满足 1%/1mm 标准的体素百分比至少为 98%。当使用 Pin、Transmission、Flat-Transmission、Flat-Absorbing 或 Absorbing 方法时,在所有测试病例中,满足该标准的点的平均值分别为 97%、88%、74%、68%或 65%。然而,与 EGSnrc 计算相比,VMC++的效率增益高达 10 倍,吸收方法的效率增益高达 48 倍。

结论

本研究结果表明,在初始治疗计划过程中,可以选择使用简单的传输技术,然后在接受更长计算时间的情况下,使用更精确的传输方法进行最终剂量计算。

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