Grabiec Marek, Walentowicz Małgorzata, Marszałek Andrzej
Department of Obstetrics and Gynecology, Collegium Medicum in Bydgoszcz Nicolaus Copernicus University, Toruń, Poland.
Ginekol Pol. 2010 Feb;81(2):140-3.
Metastases to the skin occur rarely in the cervical carcinoma, even in terminal stage of the disease. The frequency of metastasis is estimated from 0.01% to 2%. The presence of metastasis suggests generalized dissemination of the disease and reflects a rapidly progressive process that appear in the final stage of the disease.
We present a case of skin metastases in patients with squamous cell carcinoma of the cervical stump after the previous supracervical hysterectomy for benign disease of the uterus. The extensive skin changes on vulva and perineum occurred after radical trachelectomy and external radiation therapy. Patient received HDR brachytherapy for recurrent lesions, but the effect of treatment was poor and she died of progressive disease.
As far as we know this is the first case report of squamous cell carcinoma in the cervical stump metastasizing to skin. Palliative brachytherapy has a limited role in controlling symptoms. Skin metastases indicate an aggressive and progressive process.
宫颈癌转移至皮肤的情况很少见,即使在疾病晚期也是如此。转移频率估计为0.01%至2%。转移的出现提示疾病已发生全身播散,反映了疾病晚期出现的快速进展过程。
我们报告一例既往因子宫良性疾病行宫颈上子宫切除术的宫颈残端鳞状细胞癌患者发生皮肤转移的病例。在外阴和会阴出现广泛皮肤改变是在根治性宫颈切除术和体外放疗之后。患者接受了高剂量率近距离放疗以治疗复发病变,但治疗效果不佳,最终死于疾病进展。
据我们所知,这是首例宫颈残端鳞状细胞癌转移至皮肤的病例报告。姑息性近距离放疗在控制症状方面作用有限。皮肤转移表明疾病具有侵袭性且呈进展性。