病例报告：宫颈鳞状细胞癌肺转移后出现外阴转移，一例病例报告及文献综述
Case report: Vulvar metastasis after lung metastasis in cervical squamous cell carcinoma, a case report and literature review.
作者信息
Liao Ze-Lan, Wang Ka-Na, Zhang Jia-Wen
机构信息
Department of Obstetrics and Gynecology, Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu, China; Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
出版信息
Int J Surg Case Rep. 2025 Feb;127:110816. doi: 10.1016/j.ijscr.2025.110816. Epub 2025 Jan 4.
INTRODUCTION AND IMPORTANCE
Cervical cancer is highly correlated with high-risk human papillomavirus (HPV) infection, accounting for approximately 70 % of cases. However, false-negative HPV test results can occur, complicating early detection.
CASE PRESENTATION
We introduce a rare case of cervical cancer with lung metastasis followed by vulvar metastasis. Notably, the HPV test was negative at diagnosis but became positive upon detection of vulvar metastasis.
CLINICAL DISCUSSION
We discuss the pathways of vulvar metastasis in cervical cancer and potential causes of false-negative HPV tests. A search for cases of vulvar metastasis of cervical cancer in Medline and Embase between 2004 and 2024 was performed and a literature review was conducted.
CONCLUSION
The occurrence of vulvar metastasis indicates the terminal manifestation of the tumor and the survival period is short. Active radiotherapy, chemotherapy, immunotherapy and other multiple treatments may increase the overall survival time of patients.
引言与重要性
宫颈癌与高危型人乳头瘤病毒（HPV）感染高度相关，约占病例的70%。然而，HPV检测结果可能出现假阴性，使早期检测复杂化。
病例报告
我们介绍一例罕见的宫颈癌伴肺转移，随后出现外阴转移的病例。值得注意的是，诊断时HPV检测为阴性，但在外阴转移时变为阳性。
临床讨论
我们讨论了宫颈癌外阴转移的途径以及HPV检测假阴性的潜在原因。检索了2004年至2024年间Medline和Embase上宫颈癌外阴转移的病例并进行了文献综述。
结论
外阴转移的发生表明肿瘤已处于终末期，生存期短。积极的放疗、化疗、免疫治疗等多种治疗可能会增加患者的总生存时间。
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