苦橘素 A 和 B，来自海洋海绵 Phorbas gukulensis 的细胞毒性四萜。

Gukulenins A and B, cytotoxic tetraterpenoids from the marine sponge Phorbas gukulensis.

机构信息

Department of Oceanography, Kunsan National University, Jeonbuk, 673-701, South Korea.

出版信息

J Nat Prod. 2010 Apr 23;73(4):734-7. doi: 10.1021/np900606h.

PMID:20232859

Abstract

Gukulenins A (1) and B (2), both having an unprecedented skeleton with a bis-tropolone moiety, were isolated from the Korean marine sponge Phorbas gukulensis. They exhibited significant cytotoxicity against human pharynx, stomach, colon, and renal cancer cell lines in the range 0.05-0.80 microM.

摘要

从韩国海洋海绵 Phorbas gukulensis 中分离得到了具有空前骨架的 Gukulenins A（1）和 B（2），它们都具有双三酮部分。它们对人咽、胃、结肠和肾癌细胞系的细胞毒性在 0.05-0.80 μM 范围内具有显著的细胞毒性。